Please activate JavaScript!
Please install Adobe Flash Player, click here for download
ePaper created 2017-03-17, 11:08:54 | version 1.38.0
B o n e a u g m e n t a t i o n u s i n g p o r o u s (cid:696)-TC PB o n e a u g m e n t a t i o n o f c a n i n e f r o n t a l s i n u s e s u s i n g a p o r o u s (cid:696)-t r i c a l c i u m p h o s p h a te Bone augmentation of canine frontal sinuses using a porous (cid:696)-tricalcium phosphate for implant treatment Masataka Hirose,a Naoya Uemura,a Yoshiya Hashimoto,b Isumi Todac & Shunsuke Babaa a Department of Oral Implantology, Osaka Dental University, Hirakata, Japan b Department of Biomaterials, Osaka Dental University, Hirakata, Japan c Department of Anatomy, Osaka Dental University, Hirakata, Japan C o r r e s p o n d i n g a u t h o r : Dr. Yoshiya Hashimoto Department of Biomaterials Osaka Dental University, 8-1 Kuzuhahanazono-cho Hirakata 5731121 Osaka Japan yoshiya@cc.osaka-dent.ac.jp H o w t o c i t e t h i s a r t i c l e : How to cite this article: Hirose M, Uemura N, Hashimoto Y, Toda I, Baba S. Bone augmentation of canine frontal sinuses using a porous (cid:696)-tricalcium phosphate for implant treatment. J Oral Science Rehabilitation. 2017 Mar;3(1):44–51. Abstract O b j e c t i v e Compared with hydroxyapatite, alpha-tricalcium phosphate ((cid:834)-TCP) is more biodegradable and shows better integration during physiological bone remodeling. The objective of this study was to evaluate the efects of porous (cid:834)-TCP as a tissue-engineered scafold for maxillary sinus aug- mentation in a canine model. M a t e r i a l s a n d m e t h o d s Porous (cid:834)-TCP was prepared by pulverizing an (cid:834)-TCP block with an 80% continuous pore structure. Bilateral sinus floor augmentation surgeries were performed on beagle dogs that were randomly divided into two groups based on the type of repair: The experimental group received a porous (cid:834)-TCP and titanium (Ti) implant, and the control group received a Ti implant. Periimplant bone volume (BV) and bone mineral content (BMC) were measured and analyzed using micro-computed tomography (micro-CT) and Villanueva–Goldner staining for histological examination. The intergroup diferences were evaluated using the Student’s t-test. R e s u l t s Micro-CT images at 12 weeks after surgery showed higher BV and BMC in the experimental group than in the control group (p < 0.05). Histolog- ical examination showed high levels of (cid:834)-TCP even at four weeks, but the scafolds were completely absorbed and new bone integrated into the Ti implants at 12 and 24 weeks. However, no bone formation was observed in the control group throughout the study. C o n c l u s i o n Porous (cid:834)-TCP increased BV and promoted bone mineralization and ear- lier bone formation in the augmented maxillary sinus. Therefore, this tissue-engineered scafold might be a better alternative to autologous bone for maxillary sinus augmentation. K e y w o r d s Bone augmentation, porous (cid:834)-tricalcium phosphate, canine frontal sinuses. 44 Volume 3 | Issue 1/2017 Journal of Oral Science & Rehabilitation