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I m p l a n t a n d o r t h o d o n t i c t r e a t m e n t vide esthetic anterior tooth shape and correct agenesis, patients must be informed of their total dental needs, not just those associated with a limited specialty. In order to integrate and co- ordinate treatment, patients need to be ofered a total treatment approach that maximizes func- tion, esthetics and oral health. In many common dental malocclusions, orthodontic treatment alone may not be enough.18 Computer-assisted, template-based implant placement may help clinicians to perform suc- cessful implant therapy, avoiding elevation of large flaps or even eliminating flaps completely and thereby causing less pain and discomfort to patients, particularly in complex cases.19–22 Cor- rect estimation of the bone condition and the implant position and precise drilling into the bone according to the preoperative planning may be essential in ensuring the successful placement of an implant. Conclusion Comprehensive interdisciplinary rehabilitation according to the CRANIO philosophy was efec- tive in successfully restoring function and es- thetics in a young female patient afected by congenitally missing maxillary lateral incisor. Competing interests The first author (MT) is the Research and Scien- tific Project Manager at Osstem AIC, Italy. Oss- tem, Seoul, South Korea, the manufacturer of the implant system evaluated in this investiga- tion, kindly donated the implant placed. However, the data remained that of the authors and in no manner did the manufacturer interfere with the conduct of the trial or the publication of the results. References 1. Kiliaridis S, Sidira M, Kirmanidou Y, Michalakis K. Treatment options for congenitally missing lateral incisors. → Eur J Oral Implantol. 2016;9 Suppl 1:S5–24. 7. Kokich VO Jr. Congenitally missing teeth: orthodontic management in the adolescent patient. → Am J Orthod Dentofacial Orthop. 2002 Jun;121(6):594–5. 13. 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