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G u i d e d b o n e r e g e n e r a t i o n i n p e r i i m p l a n t i t i s t h e r a p y Table 1 Implant system Number of implants inserted Number of explantations % loss due to explantations 2.62 1.78 11.80 3.53 7.27 4.55 1.31 3.23 0.00 11.50 13.40 2.70 0.00 9.26 2.18 9.68 14.50 5.45 Table 1 Distribution of implant systems: overall inserted implants and implants afected by periimplantitis between 1993 to 2014. ANKYLOS ASTRA TECH CAMLOG .Cylinder Line CAMLOG Screw Cylinder Line CAMLOG ROOT-LINE CAMLOG SCREW-LINE CAMLOG SCREW-LINE Promote plus CAMLOG iSy Dentegris FRIALIT 2 IMZ TwinPlus ITI Nobel Straumann XiVE Others Implant type not classified 191 1177 4888 1783 289 747 8014 62 6 2042 499 37 11 324 2430 155 69 5 21 578 63 21 34 105 2 234 67 1 30 53 15 10 Total 22724 1239 NBCM had been performed in 20 implants (12.7%) before or simultaneously with the im- plantation. Autologous bone had been used ad- ditionally for one of these. No initial augmenta- tion had been performed in 127 implants (80.4%), while this information was not available for 11 implants (6.96%). The augmentation rate of all 22,724 implants inserted between 1993 and 2014 was 31%. In an additional subanalysis, for all 22,724 implants, the explantation rate was evaluated per implant system (Table 1). Of these, 1,239 implants were explanted owing to periim- plantitis (5.45%). The highest rates of explanta- tions were noted for the CAMLOG Cylinder Line, FRIALIT 2 and IMZ TwinPlus. Statistical analysis of the null hypothesis of no association between indication class and the need for implant therapy applying the chi- squared test yielded a p-value of 0.0056. Thus, at the 5% level of significance, the hypothesis of no diferences across indication classes with respect to the need for periimplantitis therapy might be withdrawn. Comparing the implant indication classes between all 22,724 implants and the 158 implants that underwent periim- plantitis therapy, free-end situations (indication Class IIb) tended to be more frequent in the periimplantitis group (p = 0.07), while interden- tal spaces (indication Class IIa) were significantly less frequent (p = 0.02). The frequencies of all other indication classes were not significantly diferent between all inserted implants and im- plants that underwent periimplantitis therapy (Fig. 8). However, in 2,728 of all 22,724 inserted implants (12%), the indication class could not be evaluated retrospectively. Discussion The retrospective evaluation presented here focused on the treatment of patients with im- plants placed between 1993 and 2014 in our practice and later treated again owing to periim- plantitis. Of the implants that received periim- plantitis therapy with or without GBR, treatment was successful in terms of stable reduction in PPD and BOP and implant survival of 90.5%, as only 15 of the 158 implants had to be extracted despite periimplantitis therapy over the obser- vation period of our evaluation. Our findings are in accordance with several reviews reporting successful surgical therapy of periimplantitis despite disease progression or recurrence.7, 10, 19, 20 A recent meta-analysis com- pared the results for PPD reduction and radio- Journal of Oral Science & Rehabilitation Volume 3 | Issue 1/2017 39