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ePaper created 2015-11-17, 15:11:47 | version 1.38.0
24 Volume 1 | Issue 1/2015 Journal of Oral Science & Rehabilitation β-TC P b ov in e b iph a s ic bi o mate r i al i ncre ase s bo ne f o rmati o n i n do g mo de l weeks,whereasacollagen-freelayerwaspres- ent around the silicon-free β-TCP implants. These findings suggest that the incorporation of silicate ions into β-TCP ceramics promoted bone remodeling processes at the β-TCPss– bone interface, so that the stability rate of the β-TCPss material decreased.14 Apparently, the organized collagen network facilitated the later mineralization of the collagen matrix, aided bythe silica content. Moreover,the intro- duction of calcium silicate into porous TCP bio- ceramics is an effective way to prepare bio- active bone grafting scaffolds for clinical use and to control properties such as in vivo degradability and osteoinduction ofTCP.27 In the present study, new bone formation was higher in Tests B and A in comparison with the control group, which showed maximum new bone formation after 12 weeks. These re- sults agree with earlier studies incorporating different kinds of calcium silicate into syn- thetic ceramic cements. The incorporation of dicalcium silicate (C2S) into the structure of β-TCP improved the materials’ integration and compatibility, facilitating its capacity to bond with natural bone and improving the rate of new bone formation in comparison with a C2S-free β-TCP composition.12 According to Velasquez et al., the in vivo behavior of β-TCP ceramic and C2S-doped β-TCP compositions matched their in vitro behavior.12 The bioactiv- ity and biocompatibility of these ceramics de- pended on their initial C2S content. The results of the study suggest that doping of the β-TCP ceramic with 3% C2S promotes bone mineral- ization during implantation into natural bone. Of all the compositions tested, the biphasic material doped with 3 wt% C2S showed the greatest bioactivityboth invitro and invivo and thus could be of interest for bone restorative purposes in specific applications.12 It offers an ideal matrix in regenerative procedures and might be a promising candidate as an implant material in orthopedic, oral and maxillofacial applications owing to its mechanical and bio- logical properties.12 Conclusion Despite the limitations ofthis dog study, it may be concluded that the use of this biphasic ma- terial favors new bone formation and allows critical-size defects to heal without interfering in the regeneration process. The biphasic ma- terial with 3% silicon increased the dimen- sionalstabilityofthe graft, afeaturethat offers potential in areas that require dimensional sta- bility and replacement by bone tissue. Competinginterests Theauthorsdeclarethattheyhavenocompeting interests. Co rre spo ndi ng au tho r : Prof. José Luis Calvo Guirado Calle Mozart, 4, 1º C–D 30002 Murcia Spain T +34 968 26 8353 F +34 968 26 8353 jlcalvo@ucam.edu José Luis Calvo Guirado,† Pérez Albacete Martínez Carlos,† José Manuel Granero Marín,†‡ Rafael Arcesio Delgado Ruiz,†§ Maria Piedad Ramírez Fernández,†‡ José Eduardo Maté Sánchez de Val† Gerardo Gómez Moreno†** † International Dentistry Research Cathedra, Universidad Católica San Antonio de Murcia, Murcia, Spain ‡ Faculty of Medicine and Dentistry, University of Murcia, Spain § Department of Prosthodontics and Digital Technology, Stony Brook University, School of Dental Medicine, Stony Brook, N.Y., U.S. ** Department of Pharmacological Interactions, Faculty of Dentistry, University of Granada, Spain T +34968268353 F +34968268353