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ePaper created 2015-11-17, 15:11:47 | version 1.38.0
Various authors have proposed that micro- biological contamination of the internal im- plant connection indicates bacterial leakage along the implant–abutment interface, abut- ment–prosthesis interface, and restorative margins.13, 14 The results of the present study confirm viral leakage with the presence of EBV in the implant connection, even if with a lower detection frequency with respect to the peri- implant sulci. Three periimplantitis-affected implants and three healthyimplants presented withEBVwithnostatisticallysignificantdiffer- ences between the two groups. That slightly less of the virus was found in patients with periimplantitis-affected sites compared with healthysites mayindicatethatthe intensive lo- cal immune response in the case of peri- implantitis reduces the amount of virus. How- ever, in four sites, the virus was only found in the periimplant sulci. This could confirm the impressive turnover and interaction between bacteria and viruses, which could only be sup- posed in a retrospective study with one time point such as the present one. This particular interaction is likely mediated by cytokines pro- duced during viral and bacterial infections. Tumornecrosisfactorα,interleukin1andinter- leukin 6 have a great impact on the pathogene- sis of periimplantitis. In this paper, we focused our attention on virus detection only and maybe this is the most important limitation of the study. For this reason, an observational prospective study focused also on bacteria could clarify the interactions between these microbiota and maybe the microbiological sce- nario of periimplantitis. Conclusion Withinthelimitsofthepresentstudy,nostatisti- cally significant differences were found regard- ingthepresenceofEBVinhealthyorperiimplan- titis-affected sites.This studyfailedtofind a link between periimplantitis etiopathogenesis and viralinfection. Competinginterests The authors declare that theyhave no conflict of interestsrelatedtothisstudy.Thestudywaspar- tially supported by Institute Clinident (Aix-en- Provence, France), which provided technical support, and Sweden & Martina (Padua, Italy), whichprovideddiagnostictestkits. Acknowledgments The authors wish to acknowledge the skills and commitmentofDr.AudrennGautierinthesuper- visionofthestudy. Volume 1 | Issue 1/2015 39Journal of Oral Science & Rehabilitation Epste i n–B arr vi ru s and pe r i i mplanti ti s Co rre spo ndi ng au tho r : Dr. Luigi Canullo Via Nizza 46 00198 Rome Italy T + 39 347 620 1976 F + 39 06 841 1980 luigicanullo@yahoo.com Luigi Canullo,† Paolo Pesce,‡ Nathalie Pailler,§ Matteo Simonetti,‡ Mia Rakic,** Tanja Jovanovic†† † Private practice in Rome, Italy, and Istituto Stomatologico Toscano, Viareggio, Italy ‡ Department of surgical and diagnostic sciences, University of Genoa, Italy § Institut Clinident, Aix-en-Provence, France ** Institute for Biological Research “Siniša Stanković,” University of Belgrade, Serbia †† Institute for Microbiology and Immunology, School of Medicine, University of Belgrade, Serbia T + 393476201976 F + 39068411980