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literature review _ CAD/CAM material and systems of restorations; especially when high production levels are expected. However, there are a limited number of clinical studies and the diversity of the results between systems and protocols does not allow us to give a definitive conclusion. L’articolo è stato pubblicato su Cad/Cam International, n.3 2016. _authors Dr Christian Brenes, DDS. Master in Prosthodontics. Clinical Assistant Professor Dental College of Georgia at Augusta University. International speaker for Digital Dentistry Education and BlueSkybio Academy on guided surgery, clinical digital protocols and dental aesthetics. He can be contacted at: christian@blueskybio.academy Dr Ibrahim Duqum, DDS. MS. Clinical Assistant Professor. Department of Prosthodontics at the University of North Carolina at Chapel Hill. Dr Gustavo Mendonza, DDS. MS. PhD. Clinical Associate Professor. Department of Biologic and Materials Sciences, Division of Prosthodontics, University of Michigan School of Dentistry. computer aided manufacturing is dependent on the calibration of hardware with software in the workflow. Furthermore, the virtual configuration of the die spacer between the tooth and the res- torations is essential for the accuracy of the mar- ginal adaptation and has to be calibrated for each one of the systems. Weittstein et al. demonstrated that the difference of fit between CAD/ CAM res- torations is directly related to the gap parameters from the computer design and also related to the intrinsic properties of the CAD/CAM system.16 _Conclusion This review of current and past literature regarding the evolution, characteristics, and marginal fit of milled CAD/CAM all-ceramic res- torations materials and systems show that it is possible to fabricate restorations with the same marginal fit expected from conventional methods and within the range of clinically accepted resto- rations. When comparing both methods the ad- vantage of using CAD/CAM technology is not to obtain the most precise level of fit, but rather to obtain a high level of reliability in a large number _references 1. Miyazaki T, Hotta Y, Kunii J, Kuriyama S, Tamaki Y. A review of dental CAD/CAM: current status and future perspecti- ves from 20 years of experience. Dent Mat Journal 2009. 28: 44-56. 2. Fasbinder DJ. 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