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ePaper created 2017-05-12, 09:42:21 | version 1.38.0
| research Fig. 2a Fig. 2b Fig. 2c Fig. 3a Fig. 3b Figs. 2a–c: Animal study protocol with immediate loading. Figs. 3a & b: Linear measurements (in mm): peri-implant mucosa (PM), buccal bone crest (BC), lingual bone crest (LC), top of the implant shoul- der (IS), bone crest (BC), distance from the implant shoulder at buccal bone crest (IS-BC), distance from the implant shoulder at lingual bone prosthetic components—such as loss of soft tis- sue or early marginal bone loss—are reduced or eliminated. This article demonstrates the reliabil- ity of the single-session protocol using digital methods for scanning and producing crowns complemented with platform switching and eval- uates the peri-implant soft-tissue seal. Material and methods crest (IS-LC). Animal protocol An animal experiment was conducted to evalu- ate an implant placement protocol with immediate loading using PEEK and CEREC and to assess the peri-implant soft tissue. Forty-eight blueSKY implants (bredent medical) were placed in healing bone. Thirty-two SKY elegance abutments ( bredent medical) were used in the test group and sixteen titanium abutments in the control group (Fig. 1). A randomization scheme was generated using the website www.randomization.com. The Ethics Committee for Animal Research of the University of Murcia, Spain, approved the study protocol, which followed the guidelines established by Directive 2010/63/EU on the protection of animals used for scientific purposes. Six American Foxhound dogs approximately one year of age, each weighing ap- proximately 13–15 kg, were used in the study. Day 0 (first stage) The animals were pre-anaesthetized and taken to the operating theatre where, at the earliest oppor- tunity, an intravenous catheter was inserted into the cephalic vein and propofol was infused at the rate of 0.4 mg/kg/min as a slow constant-rate infu- sion. Conventional dental infiltration anaesthesia was administered at the surgical sites. Premolar and molar extractions (P2, P3, P4, M1) were performed in both mandibular quadrants of each dog. Day 60 (second stage) After drilling, the sequence of placement of four implants by hemi-mandible was randomly planned(using randomization as mentioned). The implants were inserted in healed bone at the sites of the mandibular premolars and molars (P2, P3, P4, M1), with an insertion torque of 30 Ncm or more (Figs. 2a–c). Analysis (eight weeks after implantation) – Histological and histomorphometric analysis of the bone-to-implant contact area (BIC) with lin- ear measurements in millimetres: peri-implant mucosa (PM), buccal bone crest (BC), lingual bone crest (LC), top of the implant shoulder (IS), bone crest (BC), distance from the implant shoul- der at buccal bone crest (IS-BC), distance from the implant shoulder at lingual bone crest (IS-LC) (Figs. 3a & b). – Primary stability was evaluated by measuring the ISQ by Osstell Mentor at the time of placement. – The radiological analysis was performed using a standardized protocol. Human protocol The research protocol called for recruitment of subjects among patients referred to the Department of General Dentistry, University of Murcia, Spain, during an 18-month period. All those in need of anterior oral rehabilitation that would include single-implant placement were invited to take part in the study, which was overseen by the institutional review board. 08 implants 2 2017