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ePaper created 2018-04-10, 12:30:21 | version 1.38.0
| research L-PRF in different intraoral applications Part I: Preparation of L-PRF Prof. Nelson R. Pinto1, Dr Andy Temmerman2, Ana B. Castro2, Simone Cortellini2, Prof. Dr Wim Teughels2 & Prof. Dr Marc Quirynen2 1 Department of Periodontology and Oral Implantology, Faculty of Dentistry, Universidad de Los Andes, Santiago, Chile 2 Department of Oral Health Sciences, Section of Periodontology, KU Leuven & Dentistry, University Hospitals, KU Leuven, Leuven, Belgium Favourable wound healing has always been a major quest in dental surgery. It is a concern in healthy as well as compromised patients. In an effort to improve and accelerate healing of both hard- and soft-tissues, sub- stitutes including growth factors and biomaterials have been traditionally employed. Membranes were also intro- duced to separate tissues. Recent research clearly indicates that L-PRF (leuko- cyte- and platelet-rich fibrin, a second generation of plate- let concentrates) significantly enhances wound healing in both soft- and hard-tissues. Evidence now supports the assertion that this has the potential to replace the above mentioned substitutes in many situations. Clinical procedures benefit from recent advance- ments with platelet concentrate protocols including, but not limited to: soft tissue healing, plastic periodontal surgery, gingiva enlargement, MRONJ, regeneration of infra-bony defects, ridge preservation, sinus augmenta- tion, immediate implant placement and implant osseo- integration itself. Major indications for the use of L-PRF are Implant coating · · Wound healing · Ridge preservation · Immediate implant · Floating implant · Soft tissue R · MRONJ · Sinus R · Infra-bony R An added benefit is that these platelet concentrate pro- tocols offer significantly lower cost treatment solutions to our patients, due to the fact of their ease of use and inexpensive preparation. Major indications Our basic knowledge of the biologic mechanisms of both soft- and hard-tissue healing has increased exponen- Fig. 1a Fig. 1b Figs. 1a & b: Venipuncture and blood collection using 21 G butterfly needle and 9 ml red cap tubes. 06 1 2018