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03 AD Dental Tribune Asia Pacific Edition | 10/2017 ASIA PACIFIC NEWS Newly created protein may be promising for anti-caries vaccine By DTI WUHAN, China: Researchers from the Wuhan Institute of Virology at the Chinese Academy of Sciences have created a fusion protein (formed through the joining of genes that originally coded for separate proteins) that might be the key to developing a vaccine against dental caries. According to the research team, their sec- ond-generation fusion protein provides high protective efficacy against caries, but with lower side-effects than with previously created proteins. The research, which was sup- ported by grants from the Na- tional Natural Science Foundation of China and the German Re- search Foundation, is an advance- ment on previous studies on the fusion protein KF-rPAc. While KF-rPAc provided prophylactic and therapeutic efficiency against car- ies, it also demonstrated possible side-effects, such as high anti- genicity and potential inflamma- tory injury, that restricted its clin- ical usage. Aiming to avoid these draw- backs, the researchers created KFD2-rPAc, which induced fewer systemic inflammatory responses in animal trials, among other ef- fects. Although there is still a long way to go until a vaccine for use in humans will be available, the characteristics of KFD2-rPAc make the protein a promising vaccine candidate against dental caries, the researchers con- cluded. The results were published in a paper titled “Second-generation flagellin-rPAc fusion protein, KFD2-rPAc, shows high protective efficacy against dental caries with low potential side effects” on 11 September in the Scientific Reports journal. Chineue reuearcheru have created a fuuion protein that could be key for developing an anti-carieu vaccine in the future. The protective fluoride varnishFluor Protector N www.ivoclarvivadent.comIvoclar Vivadent AGBendererstr. 2 | 9494 Schaan | Liechtenstein | Tel. +423 235 35 35 | Fax +423 235 33 60Superior protection against dental caries and erosion • Homogeneous solution• Immediately ready for use • High-yield delivery formThe varnish for an immediate fluoridation of enamel© REDPIXEL.P/shutterstock.com© nfmlk/shutterstock.com