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02 Dental Tribune Nordic Edition | 4/2016 NORDIC NEWS IMPRINT PUBLISHER: Torsten OEMUS MANAGING EDITOR DT NORDIC EDITION: Kristin HÜBNER k.huebner@dental-tribune.com GROUP EDITOR: Daniel ZIMMERMANN CLINICAL EDITOR: Magda WOJTKIEWICZ ONLINE EDITOR: Claudia DUSCHEK EDITOR: Anne FAULMANN COPY EDITORS: Sabrina RAAFF, Hans MOTSCHMANN PRESIDENT/CEO: Torsten OEMUS CFO/COO: Dan WUNDERLICH MEDIA SALES MANAGERS: Matthias DIESSNER Peter WITTECZEK Maria KAISER Melissa BROWN Weridiana MAGESWKI Hélène CARPENTIER Antje KAHNT INTERNATIONAL PR & PROJECT MANAGER: Marc CHALUPSKY MARKETING & SALES SERVICES: Nicole ANDRAE ACCOUNTING: Karen HAMATSCHEK BUSINESS DEVELOPMENT: Claudia SALWICZEK-MAJONEK EXECUTIVE PRODUCER: Gernot MEYER AD PRODUCTION: Marius MEZGER DESIGNER: Franziska DACHSEL INTERNATIONAL EDITORIAL BOARD: Dr Nasser Barghi, Ceramics, USA Dr Karl Behr, Endodontics, Germany Dr George Freedman, Esthetics, Canada Dr Howard Glazer, Cariology, USA Prof. Dr I. Krejci, Conservative Dentistry, Switzerland Dr Edward Lynch, Restorative, Ireland Dr Ziv Mazor, Implantology, Israel Prof. Dr Georg Meyer, Restorative, Germany Prof. Dr Rudolph Slavicek, Function, Austria Dr Marius Steigmann, Implantology, Germany Published by DT Asia Pacific Ltd. DENTAL TRIBUNE INTERNATIONAL Holbeinstr. 29, 04229, Leipzig, Germany Tel.: +49 341 48474-302 Fax: +49 341 48474-173 info@dental-tribune.com www.dental-tribune.com Regional Offices: UNITED KINGDOM 535, Stillwater Drive 5 Manchester M11 4TF Tel.: +44 161 223 1830 www.dental-tribune.co.uk DT ASIA PACIFIC LTD. c/o Yonto Risio Communications Ltd, Room 1406, Rightful Centre, 12 Tak Hing Street, Jordan, Kowloon, Hong Kong Tel.: +852 3113 6177 Fax: +852 3113 6199 DENTAL TRIBUNE AMERICA, LLC 116 West 23rd Street, Suite 500, New York, NY 10001, USA Tel.: +1 212 244 7181 Fax: +1 212 224 7185 © 2016, Dental Tribune International GmbH All rights reserved. Dental Tribune makes every effort to report clinical information and manufacturer’s product news accurately, but cannot assume respon- sibility for the validity of product claims, or for typo- graphical errors. The publishers also do not assume responsibility for product names or claims, or state- ments made by advertisers. Opinions expressed by authors are their own and may not reflect those of Dental Tribune International. Scan this code to subscribe our weekly Dental Tribune Nordic e-newsletter. plants. Other risk factors associ- ated with higher implant failure rates were smoking, Type 1 dia- betes, medication for high cho- lesterol and hypothyroidism, anti- depressant drugs and proton- pump inhibitors. The researchers concluded that bruxism could be associated with an increased risk of dental implant failure. However, in investigating the underlying causes, other risk factors, including implant length, implant diameter, implant surface, habits such as smoking, and intake of certain medication, have to be taken into consideration as well, the researchers emphasised. The study, titled “Bruxism and dental implant failures: A multilevel mixed effects paramet- ric survival analysis approach”, was published in the November issue of the Journal of Oral Reha- bilitation. “ Page 1 Study investigates process of tooth loss and replacement By DTI UPPSALA, Sweden: By investigating the jawbone of a 424 million-year- old fossil fish, researchers from Uppsala University in Sweden and the European Synchrotron Radia- tion Facility (ESRF) in Grenoble in France have aimed to gain insights into the process of tooth replace- ment. Their findings will help scientists better understand the underlying cellular mechanisms of tooth growth and resorption. The jaw investigated in the study originated from a fossil of the Andreolepis fish, which was found in Gotland in Sweden. Less than a centimetre in length, the microstructure of the bone is per- fectly preserved and contains a record of its growth history. Ac- cording to the researchers, the fish represents the earliest known ex- ample of tooth shedding by basal resorption. While until recently it was only possible to see internal struc- tures by physically cutting thin sections from the fossil and view- ing them under the microscope, the researchers applied a different technique, synchrotron microto- mography, in the current study. At the ESRF, they produced tomo- graphic scans that captured the same level of microscopic detail, but in 3-D and without damaging the specimen. Virtually dissecting the scan data on the computer screen, lead author Donglei Chen spent several years producing a 3-D map of the jaw’s entire se- quence of tooth addition and loss. “Every time a tooth was shed, the resorption process created a hollow where it had been attached. When the succeeding replacement tooth was cemented in place by bone of attachment, the old resorp- tion surface remained as a faint buried scar within the bone tissue,” Chen explained. “I found up to four of these buried resorption surfaces under each tooth, stacked on top of each other like plates in a cup- board. This shows that the teeth were replaced again and again dur- ing the life of the fish.” This is the first time that an early fossil dentition has been an- alysed in such detail, the research team stated. The results suggest that new replacement teeth de- veloped alongside the old ones, rather than underneath them like in humans. Moreover, the mecha- nism seems to be most similar to the process of tooth replacement seen today in primitive bony fish suchasgar(Lepisosteus)andbichir (Polypterus). “The amount of biological in- formation we get from the scans is simply astonishing. We can follow the process of growth and resorption right down to cellular level, almost like in a living ani- mal,” stated Prof. Per Ahlberg, one of the leaders of the project. “As we apply this technique to more early vertebrates, we will come to understand their life processes much better—and no doubt we will be in for some major surprises.” The study, titled “The stem osteichthyan Andreolepis and the origin of tooth replacement”, was published online on 17 October in the Nature journal. The jaw investigated in the study originated from a fossil of the Andreolepis fish. A 3-D image of the jaw’s tooth replacement sequence. Replacement teeth (in gold) sitting on a stack of resorption surfaces, evidencing that this tooth site was replaced four times. In contrast, the tooth-like odontodes (in red) and the gap-filling odontodes (in pink) never experienced basal resorption. Donglei Chen spent several years producing a 3-D map of the jaw’s entire sequence of tooth addition and loss. © Uppsala University © Donglei Chen © Uppsala University Tel.: +4934148474-302 Fax: +4934148474-173 Tel.: +441612231830 Tel.: +85231136177 Fax: +85231136199 Tel.: +12122447181 Fax: +12122247185