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ePaper created 2017-12-05, 09:23:08 | version 1.38.0
C.E. article_ platelet-rich fibrin I Fig. 3 Fig. 3_PRF clots in the PRF box. Fig. 4_PRF plugs. Fig. 5_ PRF sticky bone. Fig. 6_PRF steaky bone. Fig. 4 Fig. 5 Fig. 6 molecules for more efficient cell migration. This has led to the idea of using platelets as therapeutic tools to improve tissue repair during wound healing. Because of the benefits to soft tissue, PRP is now being used all over the word for facial rejuvenation, joint regeneration, hair growth stimulation and ED treatment. And, because of the easier and less ex- pensive alternative, PRF liquid is starting to be used instead of PRP (PRP $450 vs. PRF $8 per patient). _Advantages of PRF compared with PRP A look at the advantages of PRF as compared wtih PRP: • No anticoagulants that affect the release of growth factors • No drugs (calcium chloride) that could affect fibrin polymerization • No animal products (Bovine thrombin) that could affect the coagulation process and immune system activation • PRF has the presence of natural fibrin network, which protects the growth factors from proteolysis. • PRF favors the development of micro vasculari- zation leading to a more efficient cell migration • PRF has the presence of monocytes, leukocytes and other white cells that have an important role during the inflammatory phase of healing • PRF manufacturing requires minimum time from the doctor The manufacturing of all blood concentrates at the patient’s site of treatment brings new challenges to the dentists and staff members: Infection-control protocols, staff training, education and research of the products used during PRF manufacturing. Handling patient’s blood and manufactur- ing blood products transforms the dental office into a blood bank facility where stricter cross- contamination control protocols should be followed in order to avoid doctor’s liability risks and to comply with federal regulations of the Center for Disease Control (CDC), OSHA and to perform at the standard of care protocols for surgery. PRF is used in invasive osseous surgery close to the eyes, ear, brain and in direct contact with bone, max- illary sinus, veins, arteries and nerves that could be adversely affected, if proper contamination control protocols are not followed. All instruments used for the manufacturing of PRF should be sealed sterile and dropped into a sterile field separate from the instruments used for the removal of contaminated tissues, debridement implants 4_2017 I 05