| industry report review, I will simply state that the literature is available, and I encourage you to read it and form your opinion as a specialist based on data and clinical experience, not hearsay. The application of high-frequency vibration ef- fected upon bone metabolism is sound. In this chapter of modern orthodontics, it has been inter- esting to watch how two different companies treat and serve their customers. High-frequency vibration shook the market when it entered, but high science and down- ward price pressure made orthodontic predictability and comfort an option for all, rather than just the wealthy. As orthodontists, we know the importance of delivering not only great results, but also great customer service. The low road has been increasingly the road less travelled, while choosing the high road has made all the difference. about Dr Jonathan Nicozisis has prac- tised orthodontics since 1999 in Princeton in the US. He completed his dental education at the University of Pennsylvania in Philadelphia in the US before attending Temple University, also in Philadelphia, for his orthodontic residency. Dr Nicozisis is a member of the Edward H. Angle Society and In- visalign national speakers’ bureau and clinical research network. He is the founding orthodontist and a former scien- tific advisory board member of BAS Medical (later Corthera and acquired by Novartis in February 2010), a development stage company founded in 2003 with a mission to develop and market a novel technology to accelerate and improve the stability of orthodontic treatments. His master’s research on the use of the hormone relaxin as a therapeutic adjunct was the basis of BAS Medical’s innovative research. Dr Nicozisis serves on the scientific advisory board of Propel Orthodon- tics, a rapidly growing biotech company developing novel technologies to improve oral health. In 2014, he co-authored a textbook chapter on Invisalign with the former chairman of Temple University’s Department of Orthodontics and Align Technology’s director of research and development. Dr Nicozisis is a consultant to Smile Assist and Your Ortho Coach. Most recently, he founded the rapidly growing Aligner Intensive Fellowship Course, in partnership with Dr Maz Moshiri. 32 ortho 1 2019 References: 1 Kopher RA, Mao JJ. Suture growth modulated by the oscillatory component of micromechanical strain. J Bone Miner Res. 2003 Mar;18(3):521–8. 2 Liu D. Transmission of mechanical vibration from Ac- celeDent to dentition and skull. Poster session present- ed at: 2013 IADR/AADR/CADR General Session; 2013 Mar 20–23; Seattle, WA. Available from: https://www. researchgate.net/publication/266807821. 3 García-López S, Villanueva R, Meikle MC. The effects of gentle micropulse vibration on two types of mu- rine osteoblasts. Poster session presented at: 2015 Annual Session of the American Association of Or- thodontists; 2015 May 15–19; San Francisco, CA. Available from: http://acceledent.com/wp-content/up- loads/2016/06/2692_GarcaLpez.pdf. 4 Alikhani M, Khoo E, Alyami B, Raptis M, Salgueiro JM, Oliveira SM, Boskey A, Teixeira CC. Osteogenic effect of high-frequency acceleration on alveolar bone. J Dent Res. 2012 Apr;91(4):413–9. 5 Alikhani M, Lopez JA, Alabdullah H, Vongthongleur T, Sangsuwon C, Alikhani M, Alansari S, Oliveira SM, Nervina JM, Teixeira CC. High-frequency acceleration: therapeutic tool to preserve bone following tooth ex- tractions. J Dent Res. 2016 Mar;95(3):311–8. 6 Leethanakul C, Suamphan S, Jitpukdeebodintra S, Thongudomporn U, Charoemratrote C. Vibratory stimulation interleukin-1 beta secretion during orthodontic tooth movement. Angle Orthod. 2016 Jan;86(1):74–80. increases 7 Alikhani M, Alansari S, Hamidaddin MA, Sangsuwon C, Alyami B, Thirumoorthy SN, Oliveira SM, Nervina JM, Teixeira CC. Vibration paradox in orthodontics: anabolic and catabolic effects. PLoS One. 2018 May 7;13(5):e0196540. 8 Woodhouse NR, DiBiase AT, Johnson N, Slipper C, Grant J, Alsaleh M, Donaldson AN, Cobourne MT. force during orthodon- Supplemental vibrational tic alignment: a randomized trial. J Dent Res. 2015 May;94(5):682–9. 9 Katchooi M, Cohanim B, Tai S, Bayirli B, Spiekerman C, Huang G. Effect of supplemental vibration on ortho- dontic treatment with aligners: a randomized trial. Am J Orthod Dentofacial Orthop. 2018 Mar;153(3):336–46. 10 Miles P, Fisher E. Assessment of the changes in arch perimeter and irregularity in the mandibular arch during initial alignment with the AcceleDent Aura appliance vs no appliance in adolescents: a single-blind randomized clinical trial. Am J Orthod Dentofacial Orthop. 2016 Dec;150(6):928–36. 11 Nagaraja M, Jo H. The role of mechanical stimulation in recovery of bone loss—high versus low magnitude and frequency of force. Life (Basel). 2014 Apr;4(2):117–30. 12 Judex S, Pongkitwitoon S. Differential efficacy of 2 vi- brating orthodontic devices to alter the cellular response in osteoblasts, fibroblasts, and osteoclasts. Dose Re- sponse. 2018 Aug 16;16(3):1559325818792112.