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Dental Tribune Middle East & Africa No. 1, 2018

14 DENTAL HYGIENE Dental Tribune Middle East & Africa Edition | 1/2018 Philips Sonicare latest clinical evidence By Philips Sonicare At Philips Oral Healthcare, we take tremendous pride in the quality of our work. Behind every Philips Son- icare product is a global team of dedicated and experienced people collaborating across a spectrum of disciplines that span the continuum of product innovation. Our aim is to be an extension of the Dental Practitioner in patients’ homes, providing oral hygiene tools that meaningfully improve and sus- tain oral health, consistent with the goals that you set together with your patients. It is with this standard in mind that we critically evaluate the safety and effi cacy of the products in our pipeline. You, and your patients, deserve a foundation of evidence from which decisions about home oral care procedures and regimens can be made. Whether it’s that pa- tient whose gingival tissue could benefi t from more thorough plaque biofi lm removal, or that patient who just can’t seem to sustain a daily in- terproximal cleaning habit, we take a patient-centered, evidence-based home-care as seriously as you do. In a Special Issue of the Journal of Clinical Dentistry, fi ve full manu- scripts provide this foundation of evidence by detailing the outcomes from four clinical trials, and one meta-analysis, in which the safety and effi cacy profi le of Sonicare in- novations have been critically exam- ined. Dr. Maha Yakob, the Director of Professional Relations and Scientifi c Affairs at Philips Oral Healthcare, notes, “At Philips Sonicare, we strive to instill an evidence-based mindset in our product development process. Study 1 Study 1 served to be statistically signifi cantly superior to use of a manual tooth- brush, within 2 weeks of use, persist- ing to study conclusion at 4 weeks, in reducing surface plaque, gingivitis and gingival bleeding. (Study 1) Similar outcomes were also ob- served in a clinical trial comparison between the Philips Sonicare Flex- Care Platinum with Premium Plaque Control brush head, and a manual toothbrush, following 2 and 6 weeks of use. For example, by the Week 2 visit following use of the assigned product, the mean percent reduction from Baseline in the assessment of gingival bleeding was 47.97% for the Sonicare group, and 8.64% for the manual toothbrush group. (Study 2) The third manuscript reports on a meta-analysis that was initiated to determine whether these discrete observations of differences in plaque and gingivitis reduction between ‘sonic’ powered and manual tooth- brushes, were supported in a broad investigation of publicly available literature. The study authors queried multiple publicly accessible databas- es for clinical trial outcomes using a pre-defi ned set of keywords. There- after, they performed a composite analysis of the results. The paper, which includes data from 18 studies, also concludes that use of a high- frequency, high-amplitude sonic- powered toothbrush is superior to manual toothbrush use for reducing plaque and gingivitis. (Study 3) The fourth manuscript reports on a comparison between two pow- ered toothbrushes, the Philips Son- icare DiamondClean with Premium Plaque Control brush head, and the Oral-B 7000 with CrossAction brush head. The outcomes of this large clin- ical trial demonstrated that the Son- icare power toothbrush performed signifi cantly better than that Oral-B power toothbrush in reducing sur- face plaque, gingivitis and gingival bleeding, following 2 and 6 weeks of use when used in respective deep clean mode. In addition, the study analysis also included an insightful proportion analysis, where the per- centage of subjects who achieved at least a 20% reduction in gingivitis at Week 2 and Week 6, was signifi cantly better in the Sonicare than the Oral- B group. (Study 4) ‘non-fl osser’ The fi nal manuscript provides im- portant clinical evidence demon- strating the effi cacy of the Sonicare Airfl ossPro interproximal cleaning device. The device was developed with the in mind; that patient who just can’t seem to adopt a fl ossing regime, but who re- ally needs better interproximal oral hygiene. As such, the study was de- signed to show that manual tooth- brushing, followed by once-daily in- terproximal cleaning with Sonicare Airfl ossPro used with antimicrobial rinse, was at least as good as manual toothbrushing followed by once- daily string fl oss use, in reducing plaque and gingivitis. The study outcomes demonstrate that this is, indeed, the case at both the Week 2 and Week 4 timepoint. (Study 5) With each innovation at Philips Oral Healthcare, our collective efforts have a single overriding goal: to provide your patients the very best tools to optimize their oral health. Subjecting our products to rigorous evaluation in a clinical-trial setting is the implicit standard set to estab- lish that this is the case. Dr. Yakob comments, “We invite you to read the entire Special Issue of the Jour- nal of Clinical Dentistry so that you can critically examine this process for yourself. I am deeply commit- ted to an innovation trajectory that starts with the voice of the Dental Professional, and ends with clinically validated, meaningful results expe- rienced by patients. The fi ve manu- scripts in the Special Issue are excel- lent proof-points of this process.” You can download the full issue here: https://www.usa.philips.com/c-m- pe/dentalprofessionals/resources_ and_education/professional-educa- tion/clinical-studies For more information visit philipsoralhealthcare.com Dr Maha Yakob, the Director of Professional Relations and Scientifi c Affairs at Philips Oral Healthcare We partner with Dental Profession- als to provide oral health solutions to patients that are demonstrated as safe and effective, through rigor- ous examination in clinical trials and published in peer-reviewed jour- nals.” The fi ve articles contained in the Special Issue of the Journal of Clinical Dentistry underscore these impor- tant points, providing Dental Profes- sionals a transparent look into the clinical data that forms the basis of a suite of safety and effi cacy evidence. Taking a high-level view, the fi ve ar- ticles focus on the effect of Philips’ products on surface plaque removal, gingival bleeding and infl ammation. We have long known that the plaque coating tooth surfaces is its own, dy- namic microenvironment, where there exists a spectrum of bacterial species and their byproducts that are health or disease-associated. And we know that the character of these bio- fi lms can affect whether the adjacent host tissue, the gingiva, is healthy. As such, the clinical trials reported in the Special Issue focus on these im- portant clinical endpoints. Key facts In the fi rst man- uscript which reports a randomized, parallel-design clinical trial, the Philips Sonicare DiamondClean powered tooth- brush was ob- Study 4 Study 4 Comparison of Gingivitis Reduction and Plaque Removal by Philips Sonicare DiamondClean and a Manual Toothbrush Delaurenti M, Ward M, Souza S, Jenkins W, Putt MS, Milleman KR, Milleman JL. J Clin Dent 2017;28(Spec Iss A):A1-6. Products Subjects Design Results - Percent reduction at Week 4 Philips Sonicare DiamondClean vs. MTB 141 Mean age: 42.1 week 2 >> 4 Randomized, parallel, single-blind Key conclusion Sonicare MTB Gingivitis 25.5% 19.1% Bleeding Plaque 57.4% 34.9% 31.4% 8.0% Twice daily brushing with Philips Sonicare DiamondClean is significantly better than using a manual toothbrush for reducing plaque and improving gingival inflammation and gingival bleeding within just two weeks, persisting to four weeks. Study 2 Study 2 Comparison of Plaque and Gingivitis Reduction by Philips Sonicare FlexCare Platinum with Premium Plaque Control Brush Head and a Manual Toothbrush Jenkins W, Souza S, Ward M, Defenbaugh J, Milleman KR, Milleman JL J Clin Dent 2017;28(Spec Iss A):A7-12. Products Subjects Design Results - Percent reduction at Week 6 Philips Sonicare FlexCare Platinum vs. MTB 143 Mean age: 40 .6 week 2 >> 6 Randomized, parallel, single-blind Sonicare MTB Gingivitis 45.79% - 0.71% Bleeding Plaque -3 .14% 58.36% 46.55% -1.58% Key conclusion Twice daily brushing with Philips Sonicare FlexCare Platinum with Premium plaque control* brush head is significantly better than using a manual toothbrush for reducing plaque and improving gingival inflammation and gingival bleeding within just two weeks. Statistically significant differences in all metrics persisted until study completion at Week 6. Study 3 Study 3 An Assessment of Gingivitis Reduction and Plaque Removal by Philips Sonicare DiamondClean with Premium Plaque Control Brush Head and Oral-B 7000 with CrossAction Brush Head Starke M, Delaurenti M, Ward M, Souza S, Milleman KR, Milleman JL. J Clin Dent 2017;28(Spec Iss A):A29-35. Products Subjects Design Results - Percent reduction at Week 6 Philips Sonicare DiamondClean vs. Oral-B 7000 284 Mean age: 38.6 week 2 >> 6 Randomized, parallel, single-blind Sonicare Oral-B Gingivitis 45.68% 26.83% Bleeding Plaque 75.81% 58.76% 37.58% 20.70 % Key conclusion Philips Sonicare DiamondClean with Premium plaque control* brush head is statistically superior to Oral-B 7000® with CrossAction™ brush head and SmartGuide accessory in reducing gingival inflammation, gingival bleeding and surface plaque. *Brush head formerly called AdaptiveClean Study 5 Study 5 The Effectiveness of Manual versus High-Frequency, High-Amplitude, Sonic-Powered Toothbrushes for Oral Health: A Meta-Analysis de Jager M, Rmaile A, Darch O, Bikker JW. J Clin Dent 2017;28(Spec Iss A):A13-28. A Study to Assess the Effects of Philips Sonicare AirFloss Pro, when Used with Antimicrobial Rinse, on Gum Health and Plaque Removal Mwatha A, Olson M, Souza S, Ward M, Jenkins W, Amini P, Gallob J, Fafard T J Clin Dent 2017;28(Spec Iss A):A36-44. Products Subjects Design Results Percentage change after everyda y use High-frequency, High high-amplitude high power toothbrushes power toothbrushes vs. MTB vs. MTB 1,870 Studies: 18 Key conclusion 4 w eeks >> 3 months Randomized, controlled clinical trials more plaque removal 20% 10% greater decrease in gingivitis Products Subjects Design Results - Percent reduction at Week 4 286 week 2 >> 4 Mean age: 35.6 Randomized, parallel, single-blind MTB + AirFloss Pro + rinse MTB Gingivitis 8.52% 1.10 % Bleeding Plaque 36.79% 22.41% 4.03% 5.70% Philips Sonicare AirFloss Pro and antimicrobial rinse vs. MTB and string floss vs. MTB Key conclusion Results of this comprehensive meta-analysis showed that high-frequency, high-amplitude, sonic-powered toothbrushes decrease plaque and gingivitis significantly more effectively than manual toothbrushes in everyday use, in studies lasting up to three months. Daily use of Philips Sonicare AirFloss Pro with antimicrobial rinse as an adjunct to manual toothbrushing was shown to improve gum health and reduce plaque significantly better than manual toothbrushing alone. Moreover, a non-inferiority test showed AirFloss Pro to be similar to string floss in reducing plaque and gingivitis.

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