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A2 XX I N DUST RY N EWS XXXXX Dental Tribune U.S. Edition | September 2017 Dental Tribune U.S. Edition | February 2012 Summit planned for pediatric dentists NuSmile Ltd., a worldwide leader in pe- diatric esthetic restorative dentistry, will present the NuSmile Summit, Jan. 19-20, in Clearwater Beach, Fla. Attendees will be able to create their own schedule by choosing courses that best meet their needs. Attendees can receive up to 16 C.E. credits from courses offered by several of the world’s most respected experts in all facets of pediatric dentistry. “The 2018 NuSmile Summit is designed to help pediatric dentists and general practitioners who treat pediatric patients keep abreast of the latest advances in pediatric dentistry,” said Diane Johnson Krueger, NuSmile founder and CEO. “Our topics and speakers have been carefully chosen to enable attendees to take their practices to the next level regarding both treatment and practice management.” “We’re very excited about the line-up of distinguished experts we’ve been able to assemble to lead our seminars, including several directors from the renowned In- stitute for Pediatric Dentistry,” said Mike Loessberg, NuSmile director of sales, U.S. and Canada. “The theme of the NuSmile Summit is ‘Bringing You Next-Level Edu- cation’ to reflect our passion for helping “ CARIES, page A1 screen — via computer simulations — 500,000 drug-like compounds for bind- ing at the enzyme’s active site. Ninety compounds with diverse scaf- folds showing promise in the computer screening were purchased and tested for their ability to block biofilm formation by S. mutans in culture. Seven showed potent, low-micromolar inhibition, and one, #G43, was tested more extensively. #G43 inhibited the activity of enzymes GtfB and GtfC, with micromolar affin- ity for GtfB and nanomolar affinity for GtfC. #G43 did not inhibit the expres- sion of the gtfC gene, and it did not affect growth or viability of S. mutans and sev- eral other oral bacteria tested. Also, #G43 did not inhibit biofilm production by several other oral streptdcdccal species. In the rat model of dental caries, ani- mals on a low-sucrose diet were infected with S. mutans and their teeth were treat- AD dentists significantly enhance both the pediatric treatment their practices pro- vide and the productivity and profitabil- ity their practices deliver.” One of the Summit’s highlights will be the popular “Zirconia REINVENTED” hands-on workshop, in which Dr. David Salar and Dr. David Evans will provide comprehensive training in the art of plac- ing zirconia crowns for every primary tooth. Other treatment courses include “Radiographic Findings of Pediatric Dis- eases” by Dr. Shailesh Kottal, “Sedation Protocol” by Dr. Steven Wilson and a “New Approaches to Pediatric Pulp Therapy” workshop by Dr. Jessica Lee. the Among practice-management for Practice courses are “Strategies Growth” by Scott Lauer, “25 Things That Changed My Practice” by Dr. William Waggoner, “Overview of Employment and Compensation Issues” by Brian Colao and “Ready to Start Your Own Practice: Where to Begin?” by Matthew Veatch. The summit will be at the Grand Wynd- ham Resort in Clearwater Beach (recently named the “#1 Beach in the U.S.” by Trip Advisor). Dentists may preregister at (800) 346-5133 or www.nusmile.cdm. About NuSmile Shortly after its 1991 founding in Hous- ton by Diane Johnson Krueger, NuSmile invented its first esthetic pediatric crown. In the 25 years since, more than 4 million NuSmile crowns have been used in resto- rations. The company’s offerings include the NuSmile ZR Zirconia crown system with Try-In crowns to prevent saliva/blood contamination and NuSmile BioCem® BioActive Cement for exceptional bond strength and handling; NuSmile Signa- ture Preveneered crowns; NuSmile SSC Pre-contoured crowns; and NuSmile NeoMTA® pulp therapy medicament. According to the company, NuSmile prides itself on customer care, commit- ment to research and support of the American Academy of Pediatric Dentist- ry, International Association of Pediatric Dentistry, Canadian Academy of Pediatric Dentistry/Académie Canadienne de Den- tisterie Pédiatrique, the Institute for Pe- diatric Dentistry and other organizations dedicated to the dental care of children and the dentists who serve them. (Source: NuSmile) ed topically with #G43 twice a day for four weeks. The #G43 treatment caused very significant reductions in enamel and dentinal caries. “In conclusion,” Wu and Velu wrote in their paper, “using structure-based de- sign, we have developed a unique low- micromolar biofilm inhibitor that tar- gets S. mutans Gtfs through binding to key virulence factors, Gtfs.” Co-authors with Wu and Velu in the pa- per, “Structure-based discovery of small molecule inhibitors of cariogenic viru- lence,” are Qiong Zhang, Zhang Hua and Jing Zou, UAB department of pediatric dentistry; Bhavitavya Nijampatnam and Thao Nguyen, UAB department of chem- istry; and Xia Cai and Suzanne M. Mi- chalek, UAB department of microbiology. Funding came from National Insti- tute of Dental and Craniofacial Research grants RO1DE022350 and RO3DE025058, and National Natural Science Foundation of China grant 81400502. ‘Successful development of this selective lead inhibitor in the dental setting offers a proof of concept that selective targeting of keystone bacteria is promising for the design of new treatments.’ DENTAL TRIBUNE The World’s Dental Newspaper · US Edition PUBLISHER & CHAIRMAN Torsten Oemus t.oemus@dental-tribune.com PRESIDENT & CHIEF EXECUTIVE OFFICER Eric Seid e.seid@dental-tribune.com GROUP EDITOR Kristine Colker k.colker@dental-tribune.com EDITOR IN CHIEF DENTAL TRIBUNE Dr. David L. Hoexter feedback@dental-tribune.com MANAGING EDITOR U.S. AND CANADA EDITIONS Robert Selleck r.selleck@dental-tribune.com MANAGING EDITOR Fred Michmershuizen f.michmershuizen@dental-tribune.com MANAGING EDITOR Sierra Rendon s.rendon@dental-tribune.com PRODUCT/ACCOUNT MANAGER Humberto Estrada h.estrada@dental-tribune.com PRODUCT/ACCOUNT MANAGER Maria Kaiser m.kaiser@dental-tribune.com PRODUCT/ACCOUNT MANAGER Jordan McCumbee j.mccumbee@dental-tribune.com CLIENT RELATIONS MANAGER Leerol Colquhoun l.colquhoun@dental-tribune.com EDUCATION DIRECTOR Christiane Ferret c.ferret@dtstudyclub.com Tribune America LLC 116 West 23rd St., Ste. #500 New York, N.Y. 10011 (212) 244-7181 Published by Tribune America © 2017 Tribune America LLC, All rights reserved. Dental Tribune strives to maintain the utmost accu- racy in its news and clinical reports. If you find a fac- tual error or content that requires clarification, please contact Managing Editor Robert Selleck at r.selleck@ dental-tribune.com. Dental Tribune cannot assume responsibility for the validity of product claims or for typographical errors. The publisher also does not assume responsibility for product names or statements made by advertisers. Opinions expressed by authors are their own and may not reflect those of Tribune America. EDITORIAL BOARD Dr. Joel Berg Dr. L. Stephen Buchanan Dr. Arnaldo Castellucci Dr. Gorden Christensen Dr. Rella Christensen Dr. William Dickerson Hugh Doherty Dr. James Doundoulakis Dr. David Garber Dr. Fay Goldstep Dr. Howard Glazer Dr. Harold Heymann Dr. Karl Leinfelder Dr. Roger Levin Dr. Carl E. Misch Dr. Dan Nathanson Dr. Chester Redhead Dr. Irwin Smigel Dr. Jon Suzuki Dr. Dennis Tartakow Dr. Dan Ward