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A A P M EETIN G DENTAL TRIBUNE DENTAL TRIBUNE The World’s Dental Newspaper · U.S. Edition The World’s Dental Newspaper · U.S. Edition SEPTEMBER 2017 — Vol. 12, No. 9 www.dental-tribune.com www.dental-tribune.com DON’T BE FOOLED BY FAKES CEMENT FOR ADVANCED RESTORATIVES Company stops numerous distributors at IDS 2017 from selling knock-offs of its patented, trademarked mixing tips. ” page A4 Multisurface luting cement adheres to zirconia, lithium disilicate and other advanced restorative substrates. ” page A5 Researchers’ molecule stops caries in lab rats By Jeff Hansen, UAB News University of Alabama at Birmingham researchers have created a small mole- cule that prevents or impedes tooth cavi- ties in a preclinical model. The inhibitor blocks the function of a key virulence enzyme in an oral bacterium, a molecu- lar sabotage that is akin to throwing a monkey wrench into machinery to jam the gears. In the presence of the molecule, Strep- tdcdccus mutans — the prime bacte- rial cause of dental caries — is unable to make the protective and sticky biofilm that allows it to glue to the tooth surface, where it eats away tooth enamel by pro- ducing lactic acid. This selective inhibition of the sticky biofilm appears to act specifically against S. mutans, and the inhibitor drastically reduced dental caries in rats fed a caries- promoting diet. “Our compound is drug-like, non- bactericidal and easy to synthesize, and it exhibits very potent efficacy in vivd,” the researchers explained in an article in Scientific Reports. It is “an excellent candidate that can be developed into therapeutic drugs that prevent and treat dental caries.” About 2.3 billion people worldwide have dental caries in their permanent teeth, according to a 2015 Global Burden of Dis- ease study. Current practices to prevent cavities, such as mouthwash and tooth brushing, indiscriminately remove oral bacteria through chemical and physical means and have limited success. Caries is the Latin word for rottenness. “If we have something that can selec- tively take away the bacteria’s ability to form biofilms, that would be a tremen- dous advance,” said Sadanandan Velu, PhD., associate professor of chemistry in the UAB College of Arts and Sciences and a lead researcher in the study. “This is particularly exciting in the broad sense of targeting microbiota using chemical probes tailored to the specific pathogen within a complex mi- crobial community,” said Hui Wu, PhD, professor of pediatric dentistry, UAB School of Dentistry, director of UAB Mi- crobiome Center and a lead investigator in the study. Wu’s expertise is bacteriology and bio- chemistry, and Velu’s is structure-based drug design. Their interdisciplinary study also included researchers from the department of microbiology in the UAB School of Medicine. Research details The glucan biofilm is made by three S. mutans glucosyltransferase, or Gtf, en- zymes. The crystal structure of the GtfC glucosyltransferase is known, and the UAB researchers used that structure to ” See CARIES, page A2 Permit #1396 Bellmawr, N.J. San Antonio, TX Permit No. 1239 US Postage Paid U.S. Postage PRST STD PRSRT STD PAID New York, N.Y. 10011 New York, N.Y. 10011 Suite #500 Suite #500 116 West 23rd Street 116 West 23rd Street Dental Tribune America Dental Tribune America IMPLANT TRIBUNE SEPTEMBER: AAP TO MEET IN BOSTON Focus is on ‘Navigating the Future of Periodontology.’ ” page B1 INDUSTRY NEWS A2–A7 • NuSmile Ltd., a worldwide leader in pediatric esthetic restorative dentistry, will present the NuSmile Summit for pediatric dentists, Jan. 19-20, in Clearwater Beach, Fla. • Sulzer Mixpac continues to enforce its rights. Avoid fakes by looking for the candy-color quality seal. • Envy Self-Etch, Self-Adhesive Cement by Essential Dental Systems: Luting cement adheres to zirconia and other advanced restorative materials. • New photonic design uniformly distributes high-def light: Designs for Vision LED DayLite Micro HDi headlights optically focus the light from the LED to provide 45 percent more light with uniform distribution. • Improve your leadership skills today: Being a good dentist doesn’t make you a good leader — but mastering these skills can help. IMPLANT TRIBUNE B1–B4 • AAP will be ‘Navigating the Future of Periodontology’ in Boston in September. • Periodontal issues may conflict with conception. • AAID releases preliminary program for its 66th educational conference in San Diego. AD Seen under a microscope, mouse dental enamel treated with acid reveals interwoven mineralized rods that give teeth strength and flexibility. A molecule created by University of Alabama researchers blocks formation of the sticky biofilm that enables Streptococcus mutans to attach itself to the tooth surface and eat away the enamel. Photo/Provided by Olivier Duverger and Maria Morasso, National Institutes of Health