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prevention International magazine for oral health No. 1, 2017

feature | digital prophylaxis How chairside molecular saliva diagnostics boosts oral and systemic health BY DIRK-ROLF GIESELMANN, INSTITUTE FOR MOLECULAR DIAGNOSTICS (IMOD) The enzyme can be found everywhere in the body and is easily detectable in the crevicular fluid. An international research team has demonstrated the effectiveness and accuracy of oral saliva analysis with more than 200 studies using aMMP-8 as the gold standard for oral prevention analysis. These studies have confirmed that the level of the acute collagenolytic destruction process can indicate the lev- el of gingival, periodontal or peri-implant soft and hard tissue destruction. Thanks to the ORALyzer, aMMP-8 can be directly quantified chairside in ng/ ml—a revolution for chairside diagnos- tics. In addition, the oral microbiome can be professionally analysed in seconds. “This development is a huge step forward for in-office diagnostics. The aMMP-8 ORALyzer increases diagnostic compe- tence significantly. For dental hygiene, it is as important as an x-ray is for surgery,” stated Prof. Timo Sorsa, one of the lead- ing European oral microbiology experts at the Karolinska Institute in Stockholm. Studies show that an increasing number of patients are actually in a state of “pre-perio” or active periodon- tal degeneration. In fact, more than 40 per cent of all German patients already suffer from so-called “active periodon- tal degenerative processes”—one of the early stages of periodontal disease. As a rule, the initial destruction of the peri- odontium is overlooked, as this is not yet measurable. The average dental practice therefore loses more than a quarter of a million euros per year by not supplying the necessary preventive measures. A step forward for digital prophylaxis With the ORALyzer, the dental team can now identify this group of patients, who are in the early stages of peri- odontal disease, and treat them more effectively. The ORALyzer analyses, within minutes, the invisible collagen destruction process that is taking place in the patient’s mouth. One of the key features of the ORALyzer is its ability to take quantitative measure- ment of the concentration of aMMP-8 (ng/ml). The ORALyzer is easy to use and is delegable to the hygienist or dental assistant, while it allows for a non-invasive and pain-free experience for the patients. Furthermore, the time required for administering the test is even less than three minutes. After- wards, dental professionals can then print out the results chairside, allowing the patient to immediately observe their personalised oral health report. 80 per cent of patients invest in additional prevention treatment The prophylaxis team can now predict the subclinical tissue destruction of periodontal or peri-implant collagen and stop it by means of targeted, in- dividual preventive measures. The result? Increased patient awareness and motivation for prevention, in- by Dirk-Rolf Gieselmann Digital implantology, digital orthodontics and now, dig- ital prophylaxis? Success- ful prevention can now be accomplished sooner with new digital technology for chairside diagnosis. A breakthrough tool for digital prophylaxis, the ORALyzer, a novel molecular diag- nostics reader, is capable of precisely quantifying the concentration of certain enzymes in the saliva, gingival crevicular fluid and peri-implant sulcus fluid, which can indicate subgingival tissue destruc- tion and therefore identify the need for additional preventive treatments. The main cause of tooth loss is periodontitis. Matrix metalloproteinase-8 (aMMP-8), a collagenase-degrading en- zyme, is activated by well-known peri- odontal trigger factors in oral pathogens. The aMMP-8 enzyme is an early indicator of the beginning of periodontal degen- eration, which often shows up in saliva well before any signs of inflammation or tissue breakdown are clinically visible. 30 issue #1

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