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prevention International magazine for oral health No. 1, 2017

science | the enzymatic system We need to maintain an effective endogenous antimicrobial defence system for the prevention of caries and periodontal diseases. Such a system could be the lactoperoxidase-thiocyanate- hydrogen peroxide-system. Dr Christoph Fiolka for its active antibacterial effects on cariogenic bacteria and certain periodontal pathogens. In fact, hypothiocyanite is part of the endogenous defence system and is present in all mu- cous membranes of the human organism, as well as in saliva. Researchers at University of Greifswald, Germany have been working on the lactoperoxidase system to help patients with limited oral hygiene. A balanced oral microbiome Christoph raves over the university’s recent findings. “We both agree that we need to maintain an effective endog- enous antimicrobial defence system for the prevention of caries and periodontal diseases. Such a system could be the lactoperoxidase-thiocyanate-hydrogen peroxide-system (LPO-system). In their quantitative suspension test, raising the thiocyanate and hydrogen peroxide concentration over the physiological level alone showed a relatively low anti- microbial effect. However, the antimicrobial efficacy of the LPO-system was very high after adding lactoperoxidase. In other words, the LPO-system reduced cariogenic bacteria within 15 minutes, effectively,” he explains. Thus, the LPO- system can help regulate the necessary balance in the oral microbiome. Michel and Christoph agree that if these enzymes are present in toothpaste as well, their protective effect can be intensified, reducing the build-up of plaque and tartar and encouraging remineralisation. “A higher concentration of peroxides helps with the natural antibacterial effect of sa- liva. We know that epithelial cells provide a physical barrier against pathogenic microbes and they produce peroxide at low doses. Dr Michel Angelo Sciotti and Dr Christoph Fiolka wonder what else enzymes can do in terms of their antibacterial ac- tivity. How can they contribute to improving colds, influenza and a myriad of other illnesses and conditions? How effective are they for the prevention of xerostomia, halitosis and oral cancer—all of which have been suggested by previous studies. “We are only at the beginning,” both say simultaneously. september 2017 25

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