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ePaper created 2017-07-19, 10:47:00 | version 1.38.0
special _ emostasi stati progettati per fornire particolari proprietà fisi- che e performanti. Essi aumentano l’affinità sangue all’interno del prodotto mentre aumentano le forze inter-molecolari tra le catene polimeriche. Queste interazioni addizionali inibiscono la rapida dissocia- zione quando esposti al sangue e conservano uno stato di gel stabile per un lungo periodo di tempo. La capacità di assorbimento di liquido di WoundClot è più di 2500% del proprio peso quando è a contatto con il sangue. La formazione di matrici 3D intrappola piastrine e coagulanti in un ambiente emodinamico aumentando la concentrazione dei componenti del sangue pur mantenendo la loro mobilità e l’attività per formare un coagulo biologico. WoundClot ha un impatto considerevole sul processo di coagulazione biologico. Inizialmente, si forma una barriera mec- canica che aderisce alla cavità. Poi il massiccio as- sorbimento di piastrine contribuisce ad accelerare la formazione di un coagulo biologico. La maggiore ca- pacità di assorbimento di WoundClot consente una maggiore quantità di piastrine di essere presente nel coagulo. Inoltre, WoundClot promuove la trasforma- zione delle piastrine nel loro stato attivo, che avvia il meccanismo di coagulazione intrinseco, trasforman- do fattore Hageman (fattore XII) da inattivo ad attivo (XIIa) (Figg. 11a-11o). _bibliografia 1. Flier J.S., Underhill L.H. Molecular and cellular biology of blood coagulation. New Engl. J. Med. 326: 800-806,1992. 2. Cirino E. et al. L’impiego del Tissucol in laparoscopia. Urg.chir.comm. 1986:9:35 3. Pratesi C. et al. Vantaggi e limiti del Tissucol in chirurgia vascolare. Atti convegno Multid. Tissucol Nov. 1983. 4. Petter-Puchner AH, Froetscher W, Krametter-Froetscher R et al. The long- term neurocompatibility of human fibrin sealant and equine collagen as biomatrices in experimental spinal cord injury. Exp Toxicol Pathol. 2007 Jan;58(4):237-45. 5. Sierra DH. 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