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tooth and the restorations is essential for the accu- racy of the marginal adaptation and has to be cali- brated for each one of the systems. Weittstein et al. demonstratedthatthedifferenceoffitbetweenCAD/ CAMrestorationsisdirectlyrelatedtothegapparam- eters from the computer design and also related to the intrinsic properties of the CAD/CAM system.16 Conclusion This review of current and past literature regarding the evolution, characteristics, and marginal fit of milled CAD/CAM all-ceramic restorations materials and systems show that it is possible to fabricate res- torations with the same marginal fit expected from conventional methods and within the range of clini- cally accepted restorations. When comparing both methods the advantage of using CAD/CAM technol- ogy is not to obtain the most precise level of fit, but rather to obtain a high level of reliability in a large number of restorations; especially when high pro- ductionlevelsareexpected.However,therearealim- ited number of clinical studies and the diversity of the results between systems and protocols does not allow us to give a definitive conclusion._ References 1. Miyazaki T, Hotta Y, Kunii J, Kuriyama S, Tamaki Y. A review of dental CAD/CAM: current status and future perspectives from 20 years of experience. Dent Mat Journal 2009. 28: 44–56. 2. Fasbinder DJ. Restorative material options for CAD/CAM resto- rations. Compend Contin Educ Dent. 2002. 3. Pallesen U, van Dijken JW. An 8-year evaluation of sintered ceramic and glass ceramic inlays processed by the Cerec CAD/ CAM system. Eur J Oral Sci. 2000. 4. Kelly JR, Denry IL. Stabilized zirconia as a structural ceramic: an overview. Dent Mater 2008. 24:289–98. 5. 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A comparative study of two CEREC software systems in evaluating manufacturing time and accuracy of restorations. Gen Dent. 2005 12. Anusavice, K. Phillips' Science of Dental Materials. 12 edition. In: Saunders. Elsevier; 2014. 13. Kosmac T, Oblak C, Jevnikar P, Funduk N, Marion L. The effect of surface grinding and sandblasting on flexural strength and reliability of Y-TZP zirconia ceramic. Dent Mater. 1999 14. Raigrodski AJ. Contemporary all-ceramic fixed partial dentures: a review. Dent Clin North Am. 2004. 15. Neves F, Prado C, Prudente M, Carneiro T, Zancope K, Davi L, Mendonçe G, Cooper L, Soares C. Marginal fit evaluation with micro CT of lithium disilicate crowns fabricated by chairside CAD/CAM systems and the heat-pressing technique. J Prosthet Dent. 2014. 16. Hertlein G. Kramer M, Sprengart T, et al. Milling time vs marginal fit of CAD/CAM manufactured zirconia restorations. J. Dent Res 2003. 82:194. 17. Guazzato M, Proos K, Quach L, Swain MV. Strength reliability and mode of fracture of bilayered porcelain/zirconia (Y-TZP) dental ceramics. Biomaterials. 2004. 18. Syrek, A. Reich, G. Ranftl, D., Klein, C. Cerny, B. Brodesser, J. (2010). Clinical evaluation of all-ceramic crowns fabricated from intraoral digital impressions based on the principle of active wavefront sampling. Journal of Dentistry. 2010. 19. De Vico G, Ottria L, Bollero P, Bonino M, Cialone M, Barlattani A Jr. et al. Aesthetic and functionality in fixed prosthodontic: experimental and clinical analysis of the CAD–CAM systematic 3Shape. Oral Implantol. 2008; 1:104–115. 20. Gehrt, M. Wolfart, S. Rafai, N., Reich, S. Edelhoff, D. (2013). Clinical results of lithium-disilicate crowns after up to 9 years of service. Clinical Oral Investigations. 17(1), 275–84. 21. Gupta TK, Bechtold JH, Kuznickie RC, Cadoff LH, Rossing BR. Stabilization of tetragonal phase in polycrystalline zirconia. J Mater Sci 1978;13:1464. 22. Piconi C, Maccauro G. Zirconia as a ceramic biomaterial. Biomaterials. 1999; 20:1–25. CAD/CAM material and systems literature review | 15 CAD/CAM 3 2016 about Dr Christian Brenes, DDS. Master in Prosthodontics. Clin- ical Assistant Professor Dental College of Georgia at Augusta University. International speaker for Digital Dentistry Education and BlueSkybio Academy on guided surgery, clinical digital protocols and dental aesthetics. He can be contacted at: christian@blueskybio.academy Dr Ibrahim Duqum, DDS. MS. Clinical Assistant Pro- fessor. Department of Prosthodontics at the University of North Carolina at Chapel Hill. Dr Gustavo Mendonza, DDS. MS. PhD. Clinical As- sociate Professor. Department of Biologic and Mate- rials Sciences, Division of Prosthodontics, University of Michigan School of Dentistry. 32016