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Journal of Oral Science & Rehabilitation 34 Volume 2 | Issue 3/2016 P u l p r e s p o n s e a f t e r c a p p i n g w i t h P D G F Human pulps capped with PDGF: A pilot study Abstract O b j e c t i v e Growthfactorshaveshownthepotentialtopromoteodontoblast-likecell differentiation and inducethe formation ofreparative dentin.The aims of this pilot study were to develop a regenerative approach to pulp capping usingplatelet-derivedgrowthfactor(PDGF)BBandtodescribehistolog- ically the pulp tissue response. M a t e r i a l s a n d m e t h o d s Two third molars (Site A and Site B) were treated. Class I cavities were prepared andthe exposed pulpswere cappedwith cotton pellets embed- dedinaPDGFsolution.Teethwereextractedafter40daysandprocessed for routine histological examination. The hard bridge formation and the pulp reaction were evaluated. R e s u l t s In Site A, incomplete and thick dentin bridge formation was observed. The pulp tissue close to the remaining exposed pulp was moderately disorga- nized, with many fibroblasts and few inflammatory cells. In Site B, an in- complete dentin bridge covered part of the defect. The pulp was overall normal, but a limited area showing a clot-like tissue with manyfibroblasts and fewinflammatorycells closetothe dentin bridge interruptionwas ob- served. C o n c l u s i o n PDGF-BB did not elicit an inflammatory response and did not induce ex- tensive dentin matrix deposition. It thus appears to be a safe pulp capping agent. K e y w o r d s Histology, human platelet-derived growth factor, pulp capping, wound healing. Gaia Pellegrini,a Claudia Dellavia,a Paolo Generali,b Cristina Allievi,a Dino Rec & Giulio Rasperinia, d a Department of Biomedical, Surgical and Dental Sciences, Università degli Studi di Milano, Milan, Italy b Private practice c Department of Oral Rehabilitation, Istituto Stomatologico Italiano, Università degli Studi di Milano, Italy d Fondazione IRCCS Policlinico Ca’ Granda, Milan, Italy C o r r e s p o n d i n g a u t h o r : Dr. Gaia Pellegrini Via Mangiagalli, 31 20133 Milan Italy T +39 347 5923198 gaiapellegrini.perio@gmail.com H o w t o c i t e t h i s a r t i c l e : Pellegrini G, Dellavia C, Generali P, Allievi C, Re D, Rasperini G. Human pulps capped with PDGF: a pilot study. J Oral Science Rehabilitation. 2016 Sep;2(3):34–41. T +393475923198