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Journal of Oral Science & Rehabilitation 8 Volume 2 | Issue 2/2016 E f f e c t s o f m e l a t o n i n o n b o n e The role of melatonin in periodontal and periimplant bone homeostasis and regeneration Pablo Galindo Moreno,a Gustavo Avila Ortiz,b Hom-Lay Wang,c Miguel Padial Molina,a Inmaculada Ortega Olleraa & Francisco O’Valled a Department of Oral Surgery and Implant Dentistry, School of Dentistry, University of Granada, Granada, Spain b Department of Periodontics, College of Dentistry, University of Iowa, Iowa City, Iowa, U.S. c Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, Mich., U.S. d Pathology Department, School of Medicine, and Institute of Biopathology and Regenerative Medicine, University of Granada, Granada, Spain C o r r e s p o n d i n g a u t h o r : Dr. Pablo Galindo Moreno C/ Recogidas, 39 5º Izq 18005 Granada Spain T +34 958 52 0658 F +34 958 52 0658 pgalindo@ugr.es H o w t o c i t e t h i s a r t i c l e : How to cite this article: Galindo Moreno P, Avila Ortiz G, Wang HL, Padial Molina M, Ortega Oller I, O’Valle F. The role of melatonin in periodontal and periimplant bone homeostasis and regeneration. J Oral Science Rehabilitation. 2016 Jun;2(2):8–15. Abstract B a c k g r o u n d Melatonin, a hormone produced primarily in the pineal gland, possesses a series of biological properties that appear to have an influence on bone homeostasis. Currently, little is known about how melatonin influences bone metabolism in periodontology and implantology. O b j e c t i v e s The objectives of this study are (1) to review the properties of melatonin inregulatingbonehomeostasis;(2)todiscussitsdirectandindirecteffects on bone; and (3) to propose mechanisms for the use of melatonin as an agent to promote alveolar bone regeneration. C o n c l u s i o n Melatoninpositiveregulationofboneformationandhomeostasis,incom- bination with the inhibitory effects on bone resorption, highlights the potential use of melatonin as a marker of periodontal and periimplant bone-relateddiseases.Invitroandanimalstudiesshowpromisingresults ontheuseofmelatoninasaregenerativeagent,althoughnoclinicalstud- ies have yet been performed. K e y w o r d s Melatonin, osteoblasts, osteoclasts, periodontal disease, dental implant, free radicals. C/ Recogidas, 395º Izq T +34958520658 F +34958520658