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Journal of Oral Science & Rehabilitation No. 2, 2016

Journal of Oral Science & Rehabilitation Volume 2 | Issue 2/2016 47 moves us to reason that the beneficial effects obtained afterapplication ofautologous PRPgel maynotbemediatedonlybytheactionofgrowth factors. Considering this data, it is logical to outline several questions and doubts regarding the var- iableamountofgrowthfactors,presentingatrue abilitytointeractwiththeenvironment,thatmay be released from the PRP gel sample that is cli- nically applied. Are those growth factors the exclusive or major mediators responsible for a change in the biological conditions that lead to animprovementintissueregeneration?Doesthe fibrillarcomponentoftheclothavearoleinmod- ulating the biological response that permits a better clinical response? Or, is it a synergistic effect betweenthefibrillarscaffold and different molecular components of blood plasma, among which growth factors are present, that induces those beneficial effects? Understanding the role of each component of PRP gel in wound-healing events and the op- timalconcentrationofmoleculeswiththecapac- ity of modulating these processes remains one of the major challenges for researchers in this field of tissue engineering. In order to address those questions, further in vitro and in vivo stud- ies seekingto determinethe physical interaction of PRP elements with cell types present in the craniofacial surgical field and its impact on cell proliferation and differentiation are needed. Competing interests The authors do not have any financial interests, either directlyor indirectly, in the products listed in the study. Acknowledgments This article was supported partially by Research Group #CTS-583 (Junta de Andalucía, Spain). C o m p o s i t i o n o f P R P 1. De Pascale MR, Sommese L, Casamassimi A, Napoli C. Platelet derivatives in regenerative medicine: an update. → Transfus Med Rev. 2015 Jan;29(1):52–61. 2. 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