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NEWS NobelClinician® is now available in a new format thatcomprisesamulti-licensepackage,whichcan be tailored to your specific needs. In order to make your practice more efficient and successful,NobelBiocareisnowdeliveringtheNo- belClinician Practice Setup.Whether you work in a small or a large clinic,have your own (CB)CT scan- ner or simply want to improve collaboration be- tween team members, this package sets your practice up for success. The software can be adapted to your specific needs, so you get the solution that works best for your practice. The entire team can now access NobelClinician at any computer in the clinic or re- motely via NobelConnect, giving them the virtual toolstheyneedtosupporttreatment.What’smore, with this setup,all NobelClinician data is automat- ically stored in one location,making it easy to back up.For more information:nobelbiocare.com/prac- ticesetup Set up your Practice for success Escherichiacoliplays an important role inthedigestivesystemandispresentin every human. However, some variants of E.coli can become pathogenic when grouped together and form dangerous biofilms.Aspartofherdoctoralthesisat the Faculty of Dentistry, Ingun Lund Witsøtestedtheimpactoftwosynthetic molecules, Furanone F202 and Thio- phenone TF101, on E. coli. Both were createdattheDepartmentofChemistry atUiO.Hergoalwastoreducetheharm- fulpotentialofE.coli,mainlybydisrupt- ing the bacteria’s way of communicat- ing. She found that Thiophenone molecules were able to disrupt communication between the bacteria, pre- venting them attaching to the cells of the intestine and forming a biofilm.Consequently,substances such asThiophenone could be advantageous in the battle against antibiotic resistance,she concluded. Although her research on E.coli’s communication patterns is still at a basic stage,Witsø believes that the results are promising for a multitude of future applications and may result in new methods for combating antibioticresistance.Forexample,artificialmoleculeswiththepropertiesofThiophenonecouldbeadded to mouthwash to help loosen dental plaque more efficiently,or the substance could be incorporated into certain prostheses to reduce and prevent the formation of biofilm,Witsø said. Synthetic molecule prevents Dangerous biofilms from forming In a laboratory test series, researchers at Univer- sité Laval in Quebec tested the effectiveness of Vaccinium angustifolium Ait., an extract from the wild lowbush blueberry, against Fusobacterium nucleatum,one of the main species of bacteria as- sociated with periodontitis. They found that the polyphenol-rich extract suc- cessfully inhibited the growth of F. nucleatum, as wellasitsabilitytoformbiofilms.Thispropertymay result from the ability of blueberry polyphenols to chelate iron, the researchers said. In addition, the extract blocked a molecular pathway involved in inflammation. “Thisdualantibacterialandanti-inflammatoryac- tion of lowbush blueberry polyphenols suggests that they may be promising candidates for novel therapeutic agents,” the researchers concluded. Theyfurtherstatedthattheyaredevelopinganoral device that could slowly release the extract after toothscalingtohelptreatperiodontitis. The study, titled “Wild Blueberry (Vac- cinium angustifolium Ait.) Polyphenols Target Fusobacterium nucleatum and the Host Inflammatory Response: Potential In- novative Molecules for Treating Periodontal Diseases,”was published online on Sept.4 in the Journal ofAgricultural and Food Chemistry. Blueberry extract: A promising agent for New periodontal therapy [PICTURE: ©FUSEBULB] [PICTURE: ©MAKS NARODENKO] implants4_201448 I