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Dental Tribune U.S. Edition | November 2015A2 Publisher & Chairman Torsten Oemus t.oemus@dental-tribune.com President & Chief Executive Officer Eric Seid e.seid@dental-tribune.com Group Editor Kristine Colker k.colker@dental-tribune.com Editor in Chief Dental Tribune Dr. David L. 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DENTAL TRIBUNE The World’s Dental Newspaper · US Edition Ad harmful bacteria could grow — but the CT imaging showed that the enhanced material filled the space just as effective- ly as traditional gutta-percha. “Validating this novel material in teeth extracted from patients serves as a strong foundation for the potential translation of nanodiamond-reinforced gutta-percha toward clinical testing,” said Dean Ho, a senior author of the study and a professor of oral biology and medicine and co-director of UCLA Den- tistry’s Jane and Jerry Weintraub Center for Reconstructive Biotechnology. Supercharged with amoxicillin In the research’s second phase, the sci- entists tested nanodiamonds that had been loaded with amoxicillin, a broad- spectrum antibiotic used to combat infection. The drug-reinforced nanodi- amonds, when combined with the gutta- percha, effectively prevented bacteria growth. “The nanodiamond-enhanced gutta- percha combines many desirable prop- erties into a single platform, including vastly improved mechanical character- istics and the ability to combat bacte- rial infection following a root canal,” said Dong-Keun Lee, a postdoctoral scholar in Ho’s lab. The study involved UCLA researchers with expertise in a wide range of disci- plines — materials science, nanotechnol- ogy, drug delivery, toxicology, oral radi- ology, endodontics, microbiology and other fields. “Through their ingenuity and collabo- ration, Professor Ho’s team is poised to transform the way that dentistry is prac- ticed,” said Dr. No-Hee Park, dean of UCLA Dentistry and a co-author of the study. During the next two years, the team plans to optimize the formulation of the nanodiamond-reinforced gutta-percha and begin clinical trials at UCLA. Ho is also a professor of bioengineering and member of the UCLA Jonsson Com- prehensive Cancer Center and the Cali- fornia NanoSystems Institute at UCLA. Other authors of the study were Albert Yen of the UCLA department of bioengi- neering and UCLA School of Dentistry; and Akrivoula Soundia, Yong Kim, We- nyuan Shi, Dr. Christine Hong, Dr. Sotiri- os Tetradis, Dr. Cun-Yu Wang and Dr. Mo Kang, all of UCLA School of Dentistry. The study was supported by the Na- tional Cancer Institute, the National Sci- ence Foundation, the Wallace H. Coulter Foundation, the V Foundation for Cancer Research, the Society for Laboratory Au- tomation and Screening, and Beckman Coulter Life Sciences. (Source: UCLA School of Dentistry) “ NANODIAMONDS, page A1 NEWS