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12DentalTribune Israel Edition Research tribune JEndod 35, 15-18 4. Petrikas AZ. [Local anesthesia of the pulp and hard tissues of teeth (dissertation, Doctor of Medical Sciences)]. Moscow; University of Moscow; 1987. p. 413. Russian. 5. Malamed, S.F. The periodontal ligament (PDL) injection: An alternative to inferior alveolar nerve block. Oral Surg Oral Med Oral Pathol, 1982; 53: 117-121. 6. Kim, S. Ligamental injection: a physiological explanation of its efficacy // J. Endod. — 1986б 12.(10):486-91. 7. Malamed, S.F. Review of C-CLAD Systems. The 1-st Annual International C- СLAD Symposium 2008 p.2 Malamed, S.F 2008 8. SleeperOneПрезентация -www. dentalhitec.com/web3/en/ sleeperone-presentation_p_73.html SleeperOneпрезентация (DHT). 9. Petrikas AZ, Jakupova LA, Medvedev DV, BorodinaOE, Egorova VA, Dyubaylo MV. Vascular mechanism of spongious dental anesthesia.J.Israel DentalAssociation.2011; 28: 19-26 10. Malamed SF: Handbook of Local anesthesia Fifth edition. 2004, 399 р 11. ADA Accepted Dental Therapeutics, 35th Edition, ADA: Chicago, 1973 12. Petrikas AZ [Anesthesia in endodontics. M MIA 2009, p.212] Russian. 13. Boakes AJ, Laurence DR, O’Neil R, Verrill PJ, Verrill PJ.Adverse reactions to local anaesthetic-vasoconstrictor preparations. Br. Dent. J. 1972;133(2):137-40. 14. PetrikasAZ/Boakes AJ-Intra-osseous anesthesia. Br. dental J. 1973 v.135(4),p. 146. 15. Pashley, D.H. Systemic effects of intraligamental injections J. Endod. 1986. 12:501. 16. Smith G.N., Pashley D.H. Systemic effects of intraligamental injections / J.Endod. 1986. 12:501. 17. Lilienthal, B. A clinical appraisal of intraosseous dental anesthesia // Oral Surg. 1975, 39(5): 692-697. 18. Wood M, Reader A, Nusstein J, Beck M, Padget D, Weaver J. Comparison of intraosseous and infiltration injections for venous lidocaine blood concentrations and heart rate changes after injection of 2% lidocaine with 1:100,00 epinephrine. J Endod 2005;31:435-438 19. Peñarrocha-Oltra, A J, Oltra- Moscardó MJ, Peñarrocha-Diago M, Peñarrocha M. Side effects and complications of intraosseous anesthesia and conventional oral anesthesia. MedOralPatolOralCirBucal.2012 May 1;17(3):e430-4. 20. Yakupova, L.A. Внутрикостная дентальная анестезия в эксперименте и клинике. [Intraosseous dental anesthesia in experiment and clinic] (dissertation,Doctor of Medical Science)]. Tver, Russia: University of Tver; 2006. 121 p. Russian 21. Bigby, J., Reader, A., Nusstein, J., Beck, M. & Weaver, J. “Articaine for supplemental intraosseous anesthesia in patients with irreversible pulpitis.” J Endod 2006;32, 1044-1047. 22 Susi L, Reader A, Nusstein J, Beck M, Weaver J, Drum M. Heart rate effects if intraosseous injection using slow and fast rates of anesthetic solution deposition. AnesthProg 2008;55:9-15 23. ААЕ: INTRAOSSEOUS ANESTHESIA Colleagues for Excellence, Winter 2009,Bonus Material F, http://www.aae.org/ 24. 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Guglielmo A, Reader A, Nist R, Beck M, Weaver J. “Anesthetic efficacy and heart rate effects of the supplemental intraosseous injection of 2 percent mepivacaine with 1:20,000 levonordefrin.” Oral Surg Oral Med Oral Pathol Oral RadiolEndod 1999;87:284-93 29. Coggins R, Reader A, Nist R, Beck M, Meyers WJ. “Anesthetic efficacy of the intraosseous injection in maxillary and mandibular teeth.” Oral Surg Oral Med Oral Pathol Oral RadiolEndod 1996;81:634-41. 30. Dunbar D, Reader A, Nist R, Beck M, Meyers W. “Anesthetic efficacy of the intraosseous injection after an inferior alveolar nerve block.” J Endod 1996;22:481-6. 31. Reitz J, Reader A, Nist R, Beck M, Meyers WJ. Anesthetic efficacy of a repeated intraosseous infection given 30 min. following an inferior alveolar nerve block/intraosseous injection. AnesthProg 1998;45:143-9. 32. Medvedev DV. Эффективность и безопасность интралигаментарной анестезии пульпы и твердых тканей зуба. [Effectiveness and safety of intraligamentous anesthesia of the pulp and dental hard tissues (dissertation,Doctor of Medical Science)]. Tver, Russia: University of Tver; 2011. 169 p. Russian 33. Efimova PU Интрасептальное обезболивание твердых тканей и пульпы зуба: методика, эффективность, осложнения. [Intraseptal analgesia hard tissue and dental pulp: methods, effectiveness, complications. (dissertation,Doctor of Medical Science)]. Tver, Russia: University of Tver; 2011. 118 p. Russian Address for correspondence: Petrikas A.Z. DMD, Depatment of Therapeutic Stomatology. Tver State Medical Academy, 170100, Tver, st.Sovetska, 4. e-mail: petrikas2009@rambler.ru (8-0822) 34 86 41 Funding No external funding was made available for this project. Statement of conflict of interest As far as the authors are aware, there is no conflict of interests. Contributions of each author AZP planned the study and its design, combined the results into a single model, compiled and edited the collected material DVM conducted and analyzed research intraligamentary anesthesia OEE conducted and analyzed research intraseptal anesthesia LAY conducted and analyzed research intraseptal anesthesia EVC created drawings to work EBO translated into English text and edited it םידחוימ םיאנת ךרד םימשרנל :'לטב קבטיל ר"ד 050-5500109 (8-0822) 348641