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ePaper created 2014-07-29, 09:08:59 | version 1.30.01
I industry report Fig. 1_Panoramic X-ray shows the atrophic maxillary ridges and the insufficient thin bone of the molar area of maxilla. Fig. 2_i-CAT tomography of the posterior maxilla shows 2-4 mm of available bone. _Introduction Xenograftmaterialsarewidelyusedforsinusaug- mentation and guided bone regeneration for in- creasing the availability of bone for optimal implant placement and reconstruction of bone defects. Atelo-peptidation of Hypro-Oss is an enzymatic process that is used to eliminate the antigenic telo- peptide sequence of the bovine collagen chain in the bone granules and thus eliminates the immune re- sponse by using the atelo-collagenated bovine bone graft in augmentation procedures in humans. The non-immunogenic bovine collagen (atelo-collagen) goesthroughtheprocessoflyophilization,whichisa process of dry-freezing using sublimation that di- rectlyconvertsthefreezedwaterinHYPRO-OSS™to vaporwithoutpassingthroughtheintermediateliq- uid phase. The dry-freezed materials become highly absorbent and can be stored at room temperature. Hypro-Oss™iscomposedof30%collagentypeIfree oftelo-peptide(atelo-collagen)withnativeosteoin- ductive elements (TGF, BMPs, IGFs) and 70% native osteoconductive bovine Hydroxyapatite compo- nents.Theadvantageofthelyophilizedbovineatelo- collagen in Hypro-Oss™ as presence of sufficient amount of collagen type I that is essential for the turnover of bone and other bone growth peptides, suchasPDGF,IGF1,IGF2andTGFbeta.Itconfersthe inductivity of bone formation and gives this kind of Xenograft material an advantage upon the heated ceramicxenograftwhichcontainszeroamountofor- ganicmaterialandgrowthfactorsduetotheheating procedures. This study will evaluate the effect of bovine lyophilized atelo-collagen containing xenograft (Hypro-Oss™, Bioimplon GmbH, Germany) in sinus augmentationprocedureusingclinicalevaluationof handling, short term healing, implantation parame- ters, histological screening of the augmented site 24weekspost-augmentationandfollowupuntilos- seointegration is completed for the final loading. _Case presentation A 70-year-old edentulous lady with drug-sta- bilisedhypertensionhasunstablemaxillarycomplete denture. The patient was interested in fixed partial denture. Clinical evaluation of the maxilla presents atrophic ridges, unstable removable complete den- ture and need for massive lip support due to the at- rophicjaws,inthemandibleimplantsupportedover- denture. Radiographic evaluation demonstrates the lackofboneatverticalandhorizontaldimension,low sinus flour about 1–3 mm of residual bone at the si- nus posterior area, the sinus anatomy is regular, no septumormembraneimpairmentswasrecordedus- ing i-cat CT tomography scanning. Sinus augmentation with atelo-collagenated bovine bone graft Hypro-Oss™ Author_Dr Amir Gazmawe, Jerusalem 36 I implants2_2014 Fig. 1 Fig. 2