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Dental Tribune Middle East & Africa Edition

Sensodyne® understands that dentine hypersensitivity patients have differing needs Sensodyne® Complete Protection, powered by NovaMin® , offers all-round care with specially designed benefits to meet your patients’ different needs and preferences. With twice-daily brushing, Sensodyne Complete Protection: Clinically proven to provide dentine hypersensitivity relief1-3 Contains fluoride to strengthen enamel Helps to maintain good gingival health4-6 Sensodyne® Complete Protection, powered by NovaMin® – an advanced approach to dentine hypersensitivity relief NovaMin® , a calcium and phosphate delivery technology, initiates a cascade of events on contact with saliva7-12 which leads to formation of a hydroxyapatite-like restorative layer over exposed dentine and within dentine tubules.7, 9-13 In vitro studies have shown that the hydroxyapatite-like layer starts building from the first use7-9 * and is up to 50% harder than dentine.9,14 The hydroxyapatite-like layer binds firmly to collagen within exposed dentine10,15 and has shown in in vitro studies to be resistant to daily physical and chemical oral challenges,9,14-17 such as toothbrush abrasion16 and acidic food and drink.14-17 Sensodyne® Complete Protection helps maintain good gingival health4-6 Good brushing technnique can be enhanced with the use of a specially designed dentifrice to help maintain good gingival health.18,19 In clinical studies, NovaMin® containing dentifrices have shown up to 16.4% improvement in plaque control as well as significant reduction in gingival bleeding index, compared to control toothpastes.4-6 All-round care for dentine hypersensitivity patients1-6 Adapted from Earl et al, 2011 (A).13 In vitro cross-section SEM image of hydroxyapatite-like layer formed by supersaturated NovaMin® solution in artificial saliva after 5 days (no brushing)13 Hydroxyapatite-like layer within the tubules at the surface 5 µm Hydroxyapatite-like layer over exposed dentine In vitro studies show that a hydroxyapatite-like layer forms over exposed dentine and within the dentine tubules:7,9,10,12,13 Adapted from Tai et al, 2006.4 Randomised, double-blind, controlled clinical study of 95 volunteers given NovaMin® containing dentifrice or placebo control (non-aqueous dentifrice containing no NovaMin® ) for 6 weeks. All subjects received supragingival prophylaxis and polishing and were instructed in brushing technique.4 *GBI scale ranges from 0–3. Significant reduction in gingival bleeding index (GBI) over 6 weeks with a NovaMin® containing dentifrice4 MeanGBI* 58.8% reduction from baseline in 6 weeks with a NovaMin® containing dentrifrice4 1.4 1.2 1.0 0.8 0.6 0.4 0.2 0 NovaMin® containing dentifrice Baseline 6 weeks Baseline 6 weeks Placebo control p<0.001 p=ns References: 1. Du MQ et al. Am J Dent 2008; 21(4): 210−214. 2. Pradeep AR et al. J Periodontol 2010; 81(8): 1167−1113. 3. Salian S et al. J Clin Dent 2010; 21(3): 82-87. Prepared November 2011, Z-11-496. 4. Tai BJ et al. J Clin Periodontol 2006; 33: 86-91. 5. Devi MA et al. Int J Clin Dent Sci 2011; 2: 46-49. 6. GSK data on file (study 23690684) 7. LaTorre G, Greenspan DC. J Clin Dent 2010; 21(3): 72-76. 8. Edgar WM. Br Dent J 1992; 172(8): 305-312. 9. Burwell A et al. J Clin Dent 2010; 21(Spec Iss): 66–71. 10. Efflandt SE et al. J Mater Sci Mater Med 2002; 26(6): 557-565. 11. de Aza DN et al. J Mat Sci: Mat in Med 1996; 399–402. 12. Arcos D et al. A J Biomed Mater Res 2003; 65: 344–351. 13. Earl J et al. J Clin Dent 2011; 22[Spec Iss]: 62-67. (A) 14. Parkinson C et al. J Clin Dent 2011; 22(Spec Issue): 74-81. 15. West NX et al. J Clin Dent 2011; 22(Spec Iss): 82-89. 16. Earl J et al. J Clin Dent 2011; 22(Spec Iss): 68-73. (B) 17. Wang Z et al. J Dent 2010; 38: 400−410. 18. “Dentifrices” Encyclopedia of Chemical Technology 4th ed. vol 7, pp. 1023-1030, by Morton Poder Consumer Products Development Resources Inc. 19. van der Weijen GA and Hioe KPK. J Ciul Periodontal 2005; 32 (Supp 1.6): 214-228. Date of Preparation: July 2013, Code: CHSAU/CHSENO/0008/13 Evolving expertise in dentine hypersensitivity ® Arenco Tower, Media City, Dubai, U.A.E. Tel: +971 4 3769555, Fax: +971 3928549 P.O.Box 23816. For full information about the product, please refer to the product pack. For reporting any Adverse Event/Side Effect related to GSK product please contact us on contactus-me@gsk.com. SENSITIVE TO THE NEEDS OF YOUR DENTINE HYPERSENSITIVITY PATIENTS

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