Dental Tribune U.S. Edition

Dental Tribune U.S. Edition | February 2012XX XXXXX Dental Tribune U.S. Edition | August 2013A2 NEWS Publisher & Chairman Torsten Oemus t.oemus@dental-tribune.com President & Chief exeCutive OffiCer Eric Seid e.seid@dental-tribune.com GrOuP editOr Kristine Colker k.colker@dental-tribune.com editOr in Chief dental tribune Dr. David L. Hoexter feedback@dental-tribune.com manaGinG editOr u.s. and Canada editiOns Robert Selleck r.selleck@dental-tribune.com manaGinG editOr Fred Michmershuizen f.michmershuizen@dental-tribune.com manaGinG editOr Sierra Rendon s.rendon@dental-tribune.com PrOduCt/aCCOunt manaGer Jan Agostaro j.agostaro@dental-tribune.com marketinG direCtOr Anna Kataoka-Wlodarczyk a.wlodarczyk@dental-tribune.com eduCatiOn direCtOr Christiane Ferret c.ferret@dtstudyclub.com aCCOuntinG COOrdinatOr Nirmala Singh n.singh@dental-tribune.com Tribune America, LLC 116 West 23rd St., Ste. #500 New York, N.Y. 10011 (212) 244-7181 Published by Tribune America © 2013 Tribune America, LLC All rights reserved. Dental Tribune strives to maintain the utmost accu- racy in its news and clinical reports. If you find a fac- tual error or content that requires clarification, please contact Managing Editor Robert Selleck at r.selleck@ dental-tribune.com. Dental Tribune cannot assume responsibility for the validity of product claims or for typographical errors. The publisher also does not assume responsibility for product names or statements made by advertisers. Opinions expressed by authors are their own and may not reflect those of Tribune America. editOrial bOard Dr. Joel Berg Dr. L. Stephen Buchanan Dr. Arnaldo Castellucci Dr. Gorden Christensen Dr. Rella Christensen Dr. William Dickerson Hugh Doherty Dr. James Doundoulakis Dr. David Garber Dr. Fay Goldstep Dr. Howard Glazer Dr. Harold Heymann Dr. Karl Leinfelder Dr. Roger Levin Dr. Carl E. Misch Dr. Dan Nathanson Dr. Chester Redhead Dr. Irwin Smigel Dr. Jon Suzuki Dr. Dennis Tartakow Dr. Dan Ward Tell us what you think! Do you have general comments or criti- cism you would like to share? Is there a particular topic you would like to see articles about in Dental Tribune? Let us know by sending an email to feedback@ dental-tribune.com. We look forward to hearing from you! If you would like to make any change to your subscription (name, address or to opt out) please send us an email at database@dental-tribune.com and be sure to include which publication you are referring to. Also, please note that subscription changes can take up to six weeks to process. DENTAL TRIBUNE The World’s Dental Newspaper · US Editionwas not considered separately. Another study limitation listed by the research- ers was the inability to determine from the data exactly why tooth loss occurred, because of no uniform use of diagnostic codes being in place. The researchers also acknowledged that they were not able to compensate for potential selection biases across the study populations versus be- ing able to examine data derived from a true random sampling across the treat- ment groups being analyzed. But even with the limitations, the re- searchers concluded that the study's find- ings “may provide a proof-of-principle” that there is opportunity to provide more effective preventive oral care through the use of risk-based patient assessment that includes genetic testing. The research was conducted under the direction of Dr. William Giannobile, Najjar endowed professor of dentistry and biomedical engineering and chair of the Department of Periodontics and Oral Medicine at the University of Michigan. Sir Gordon Duff, professor emeritus of molecular medicine at the University of Sheffield (England) and co-author of the paper, said, “Personalized medicine is an important frontier in health care driven by the clinical application of genetic and molecular information. Genetic-based risk assessment has long promised to improve prevention and treatment of chronic diseases,” Dr. Kenneth Kornman, CEO of Interleu- kinGenetics,thecompanythatdeveloped the genetics test used in the study, points to the study’s findings as representing perhaps the first broad scale applica- tion of genetics to help prevent a disease that is prevalent, costly and preventable. “Dentistry has long been a leader in the delivery of preventive health care to pa- tients,” Kornman said. “The findings of this study provide dental clinicians with the opportunity to offer personalized, preventive care that is based on new in- sights into the importance of genetic risk factors.” Periodontitis initiation and progres- sion is driven by two factors: bacterial plaque that initiates the disease and the body’s inflammatory response to bacte- ria, which, when overly aggressive, can cause breakdown of the bone and tissue that support the teeth. This inflamma- tory response varies greatly within the population and is significantly influ- enced by individual genetic makeup. Genetic testing can identify patients who have an increased inflammatory response to oral bacteria, which signifi- cantly increases risk of periodontitis and tooth loss. Smoking and diabetes also contribute significantly to the risk of periodontal disease. “Ultimately, patients should be evalu- ated by their dentist regularly and receive needed preventive care before any symp- toms of periodontal disease appear. This disease can result in disfiguring bone loss around teeth and has been implicated as a risk factor for multiple systemic conditions that benefit from early stage prevention,” said periodontist Donald S. Clem, DDS, diplomate, American Board of Periodontology and past president of the American Academy of Periodontology. “Historically, we have lacked the prognos- tic tools to effectively identify patients at greatest risk for periodontitis. This study underscores the need to adopt a genetic, risk-based approach and gives patients a compelling new reason to visit the den- tist for a comprehensive periodontal evaluation. As we see with other chronic diseases, identifying and understanding genetic predisposition to disease is a criti- cal component of long-term prevention.” Periodontitis is a bacterially induced chronic inflammatory disease that de- stroys the bone and gum tissues that support the teeth. It is one of the most common chronic diseases of the body. It causes bleeding and swelling of the gums, loose teeth, bad breath and can ul- timately lead to tooth loss. According to the researchers, severe periodontitis has been associated with increased risk for a number of other diseases, including car- diovascular diseases, diabetes and rheu- matoid arthritis. The entire research paper, “Patient Stratification for Preventive Dental Care,” can be viewed on or downloaded from the Journal of Dental Research website at www.jdr.sagepub.com. The Journal of Dental Research is a peer-reviewed scientific journal focused on emerging knowledge relevant to den- tistry and the health and disease of the oral cavity and associated structures. Highlights of the study · Explores the frequency of preven- tive dental visits (dental cleanings) in adults and the role of three key risk fac- tors: smoking, diabetes and genetics in the progression of periodontal disease leading to tooth loss. · Stresses the importance of dental visits to diagnose the disease before symp- toms present. · Findings represent how genetics can be used to prevent a disease that is preva- lent, costly and preventable. · For patients with one or more risk fac- tors categorized as high risk, the tra- ditional two dental cleanings per year had significantly greater value than one cleaning in preventing tooth loss. · For high-risk patients with two or more risk factors, two cleanings per year did not appear to be sufficient to adequate- ly prevent tooth loss. About Interleukin Genetics Interleukin Genetics develops and mar- kets a line of genetic tests under the In- herent Health and PST brands. It markets its tests through partnerships with health and wellness companies, health care pro- fessionals and other channels. Products include a proprietary genetic risk panel for periodontal disease and tooth loss susceptibility sold through dentists. It is headquartered in Waltham, Mass., where it also operates a DNA testing laboratory certified under the Clinical Laboratory Improvement Amendments (CLIA). Learn more at www.ilgenetics.com. (Sources: Journal of Dental Research and Interleukin Genetics) “ PERIODONTITIS, page A1 A recent study confirms that genetic testing can identify patients who have an increased inflammatory response to oral bacteria, which can significantly increase their risk for periodontitis and tooth loss. Photo/By Dana Roth, www.dreamstime.com. 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