Dental Tribune Turkish Edition

Yenilik & Uygulamalar DENTAL TRIBUNE Türkiye Baskısı6 yondan farklı olarak daha yük- sek değerlere ulaşmaktadır.23 EGFR’ün rezin gruplarında yüksek olmasının açıklaması, bu maddelere karşı organizmanın bir savunma mekanizması geliş- tirmesidir. 10 Her ne kadar bu maddeler inert olsalar da vücut onları yabancı cisim kabul edip onlara karşı organizmayı savun- maya çabalamaktadır. Bu savun- mada lenfositler ve fibroblastlarla birlikte EGFR’de yer almaktadır. Bütün rezin gruplarınında gözlenilen EGFR ekspresyonu ar- tışı mitojenik uyarı oluşturabile- cektir. Ancak bu etki oldukça dü- şük seviyelerde görülmektedir. Yine de uzun süreli uyarıların kü- mülatif etkisi de göz ardı edilme- melidir. Çünkü EGFR’ ün kronik toksik irritasyonda, premalign lezyon oluşumu için etkili rol oy- nayabileceği bildirilmektedir.3 So- nuç olarak tüm rezin gruplarında kontrol grubundan farklı bulgular elde edilmiştir. Acron grubu kon- trol grubuna en yakın olan dola- yısıyla en az sitotoksik etki göste- ren grup olmuştur. EGFR artışı ile karakterize malign değişim bek- lenilen bir bulgu olmaktan çok uzak görülmektedir. Kaynaklar 1. Araujo CS, Graner E, Almeida OP, Sauk JJ, Coletta RD. Histomorphometric characteristics and expression of epi- dermal growth factor and its receptor by epithelial cells of normal gingiva and hereditary gingival fibromatosis. J Periodontal Res 2003, 38:237-41. 2. Baker S, Brooks SC, Walker DM: The release of residual monomeric methyl methacrylatefrom acrylic appliances in the human mounth. An assay for mo- nomer in saliva. J Dent Res 1988, 67:1295-9 3. Bergler W, Bier H, Ganzer U. The ex- pression of epidermal growth factor re- ceptors in the oral mucosa of patients with oral cancer. Arch Otorhinolary- ngol 1989, 246:121-5. 4. Christensen LH, Breiting VB, Aasted A, Jorgensen A, Kebuladze I. Long-term effects of polyacrylamide hydrogel on human breast tissue. Plast Reconstr Surg. 2003, 111:1883-90. 5. Craig,R.G.:Restorative dental materi- als.8th Ed.The C.V.Mosby Company St.Luis, Baltimore Toronto ,1989, 504- 15. 6. Cotran RS, Vinay K, Robbins SL. Rob- bins Pathologic Basis of Disease. 5th Ed. WB Saunders Comp Philadelphia 1994, 80. 7. End P, Panayotou G, Entwistle A, Wa- terfield MD, Chiquet M. Tenascin: a modulator of cell growth. Eur J Bioc- hem. 1992, 1:1041-51. 8. Goodman SB, Fornasier VL, Kei J. Qu- antitative comparison of the histologi- cal effects of particulate polymethy- lmethacrylate versus polyethylene in the rabbit tibia. Arch Orthop Trauma Surg. 1991, 110:123-6. 9. Hensten-Pettersen A, Jacobsen N. To- xic effects of dental materials. J Prost- het Dent. 1991, 41,265-73 10. Hoffmann P, Reinshagen M, Zeeh JM, Lakshmanan J, Wu VS, Goebell H, Ger- ken G, Eysselein VE. Increased expres- sion of epidermal growth factor-recep- tor in an experimental model of colitis in rats. Scand J Gastroenterol 2000, 35:1174-80 11. Ikoma K, Kusaka Y, Takamiya H, Eliav U, Navon G, Seo Y. Evaluation of colla- gen fiber maturation and ordering in regenerating tendons employing H-1 double quantum filtered NM spectros- copy. J Orthop Res 2003, 21:149-56. 12. Jorge JH, Giampaolo ET, Machado AL, Vergani CE. Cytotoxicity of denture ba- se acrylic resins: a literature review. J Prosthet Dent 2003, 90:190-3. 13. Kaaber S: Allergy to dental materials with special reference to the use of amalgam and polymethylmethacrylate. Int Dent J 1990, 40: 359-65 14. Kagiyama S, Qian K, Kagiyama T, Phil- lips MI. Antisense to epidermal growth factor receptor prevents the develop- ment of left ventricular hypertrophy. Hypertension 2003, 41: 824-9. 15. Kalıpçılar B, Karaağaçlıoğlu L, Hasan- reisoğlu U: Evaluation of the level of residual monomer in acrylic denture base materials having different poly- merization properties. J Oral Rehabil 1991, 18: 399-401. 16. Lee WJ, Park BY. The subcutaneous capsules for foreign body in fetal rab- bits: preliminary report. Yonsei Med J 2001, 42:595-601. 17. Naito Y, Yoshikawa T, Matsuyama K, Yagi N, Arai M, Nakamura Y, Nishimu- ra S, Yoshida N, Kondo M. Effects of oxygen radical scavengers on the qua- lity of gastric ulcer healing in rats. J Clin Gastroenterol. 1995, 21 Suppl 1:S82-6. 18. Peschen M, Grenz H, Grothe C, Schopf E, Vanscheidt W. Patterns of epidermal growth factor receptor, basic fibroblast growth factor and transforming growth factor-beta3 expression in skin with chronic venous insufficiency. Eur J Dermatol 1998, 8:334-8. 19. Phillips RW, Skinner’s Science of Den- tal Materials. 9th Ed. WB Saunders, Philadelphia, 1991, 208-9. 20. Ruyter IE: Release of formaldehyde from denture base polymers Acta Odontol Scand 1980, 38: 17-27. 21. Shirai H, Sato T, Hara T, Minagi S: The effect of diabetes mellitus on histopat- hological changes in the tissues under denture base and without mechanical pressure. J Oral Rehabil 1998, 25:715- 20. 22. Sheridan PJ, Koka S, Ewoldsen NO, Le- febvre CA, Lavin MT: Cytotoxicity of denture base resin. Int J Prostodont 1997, 10.73-7. 23. Uhlman DL, Adams G, Knapp D, Aeppli DM, Niehans G. Immunohistochemical staining for markers of future neoplas- tic progression in the larynx. Cancer Res 1996, 56:2199-205. 24. Vassar R, Fuchs E. Transgenic mice provide new insights into the role of TGF-alpha during epidermal develop- ment and differentiation. Genes Dev 1991, 5:714-27. 25. Weaver RE, Goebel WM: Reactions to acrylic resin dental prostheses. J Prost- het Dent 1980, 43:138-42. 26. Yunus N, Harrison A, Huggett R. Effect of microwave irradiation on the flexu- ral strength and residual monomer le- vels of an acrylic resin repair material. J Oral Rehabil 1994, 21:641-8. 27. Zenz R, Scheuch H, Martin P, Frank C, Eferl R, Kenner L, Sibilia M, Wagner EF. c-Jun Regulates Eyelid Closure and Skin Tumor Development through EGFR Signaling. Dev Cell 2003, 4:879- 89. DT Sayfa 5DT Doç. Dr. Filiz Aykent Selçuk Üniversitesi Diş Hekimliği Fakültesi, Protetik Diş Tedavisi A.D. Yazışma Adresi