DENTALTRIBUNE Middle East & Africa Edition Dental Cafe 11 action on bacteria is at the plasma membrane level (Man- del, 1988) where the positive charge creates an attraction be- tween the molecule and the neg- ativechargeofthephospholipids that make up the bacterial cell membrane. Once the molecule attaches to the membrane, the non-polar side of the CPC pene- trates and alters the cellular membrane. This alteration causes an osmotic imbalance and causes loss of cytoplasmic material and then cell death. Even though it can also stain enamel, it does this at a much lower degree than CHX. Differ- ent in vitro and in vivo studies have proven that CPC at different concentrations is effective in re- ducing supra and subgingival dental bacterial plaque, which in turn also reduces inflammatory response12,13. Likewise, work carriedoutbyRoldánetalin2003 clearly describes that a formula- tion with CPC, CHX and Zinc Lactate has very good results, significantlyeliminatinganaero- bic microorganisms, such as F. nucleatum and P. intermedia from the tongue surface and from the saliva. Similarly, a clinical study comparing different mouth- washes showed a reduction in anaerobic microorganisms in patients’ saliva samples. This same study also meas- ured the quantity of volatile sul- phur compounds (responsible forthebadodourofhalitosis)and proved that they were reduced considerablywhenusingmouth- washes with CPC as one of its ac- tive ingredients14. In a review from year 2008, van den Broek et al compared re- sults from different clinical stud- ies where the activity of different mouthwashes against halitosis was tested. They point out that studies in which products like HALITA, which contains CPC, CHX and Zinc Lactate in its for- mulaaretheonesthatyieldedthe best results. Other clinical studies have tested mouthwashes with differ- ent formulations and concentra- tions of CPC15,16. In general, their results show that this com- pound, by itself at different con- centrations has antiplaque ef- fects. It has also been combined with Sodium fluoride, alcohol and CHX with the intention of re- ducing the concentration of the two latter compounds because of their adverse effects. Thus, it has been proven that CPC can be used as a treatment for certain oral pathologies, like for instance, mucositits, espe- cially in patients who have un- dergone irradiation for head and neck cancer or those who suffer from periodontitis or gingivitis. Dr. Rubén León Director of R&D at Dentaid. B.S. in Biology and PhD in Genet- ics. What research has Dentaid carried out on the CPC mole- cule? At Dentaid, a number of stud- ies have been performed using thismolecule,thathaveledtothe confection of diverse formula- tions that currently aid in human oral hygiene. Also, among these, we have studies on antimicrobial activity, stability studies of the formulations for replacing ethanol in mouthwashes and im- proving CPC’s bioavailability. We have also carried out dif- ferent clinical studies with na- tional and foreign universities that have shown that products containing this molecule are among the most efficient on the market. Having proven the proper- ties of this molecule, how is Dentaid applying it in its prod- ucts? Dentaid has developed a line of products that contain CPC among its active ingredients, products that are meant for care and treatment of pathologies like periodontitis, gingivitis, halitosis or maintenance in patients that have been treated for periodon- titis. Currently, a group of prod- ucts is being developed where this molecule has greater bioavailability. “Dentaidhasdevelopedaline of products that contain CPC among its active ingredients” DT Page 5DT COVENTRY, UK: A woman fromCoventryhascoughedupa canceroustumour.Accordingto reports, 37-year-old Claire Os- bornhadtwocoughingfits,both of which produced pieces of the tumour. It is believed that the lump, which is thought to have been growing on the back of her throat,becamedislodgedbefore the coughing fits. Osborn took the 2 cm heart- shaped lump to the doctors. “I knew something was very wrong so I went straight to my GP,” Os- born was reported to have said. Scans showed that the tissue was in fact an aggressive throat and mouth cancer. Osborn was in- formed that there was a chance that the tumour may not be the only one in her body. “I was devastated. I just thought I was going to die,” Os- born was reported to have said. However, doctors were amazed to find that the cancerous tumour wasinfacttheonlyoneinherbody and after a scan at University Hos- pital Coventry she was given the all clear. According to one report, Osborn said: “The consultant turnedroundtomeandsaid‘Itap- pears you have coughed up your cancer. Congratulations!’”. Fewer than 30 similar cases have ever been recorded in the world. Head and neck surgeon Gary Walton was reported to have said: “We suspect the tumour grew on a stalk at the back of her mouthwhichisverydifficulttode- tect. Somehow she dislodged this, the stalk snapped and she coughed up the tumour.” DT British woman coughs up oral tumour